MCM6 抗体 (AA 228-368)
Quick Overview for MCM6 抗体 (AA 228-368) (ABIN6937817)
抗原
See all MCM6 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 228-368
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特异性
- The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM6 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1/S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the post-replicative state of the cell. MCM2/MCM6 complexes function as substrates for Cdc2/cyclin B in vitro.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant fragment (around aa 228-368) of human MCM6 protein (exact sequence is proprietary)
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亚型
- IgG2b kappa
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anti-Minichromosome Maintenance Complex Component 6 (MCM6) (AA 562-821) antibody
MCM6 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Complex Component 6 (MCM6) (AA 1-821) antibodyMCM6 适用: 人 WB, IF, IHC (p), PLA 宿主: 小鼠 Polyclonal unconjugated
anti-Minichromosome Maintenance Complex Component 6 (MCM6) (AA 228-368) antibodyMCM6 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal MCM6-2999 unconjugated
anti-Minichromosome Maintenance Complex Component 6 (MCM6) (AA 1-821) antibodyMCM6 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 7D8 unconjugated
anti-Minichromosome Maintenance Complex Component 6 (MCM6) (AA 589-605), (Middle Region) antibodyMCM6 适用: 人, 小鼠, 大鼠 IHC, WB, IF, ICC, FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Complex Component 6 (MCM6) (AA 562-821) antibodyMCM6 适用: 人 IHC, WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Complex Component 6 (MCM6) antibodyMCM6 适用: 人, 小鼠, 大鼠 IHC, WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Complex Component 6 (MCM6) (C-Term) antibodyMCM6 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔 IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Complex Component 6 (MCM6) antibodyMCM6 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Complex Component 6 (MCM6) (C-Term) antibodyMCM6 适用: 人, 犬, Cow, 豚鼠, 马, 兔 IHC, WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: Human skin or squamous cell carcinoma (IHC).
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- MCM6 (Minichromosome Maintenance Complex Component 6 (MCM6))
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别名
- MCM6
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背景
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DNA replication licensing factor MCM6, MCM6 minichromosome maintenance deficient 6, MIS5 homolog, p105MCM,MCM6 (Proliferation Marker)
Cellular localisation: Nuclear -
分子量
- 105kDa
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基因ID
- 4175, 444118
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UniProt
- Q14566
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途径
- DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
抗原
-
