KIT 抗体
Quick Overview for KIT 抗体 (ABIN6937624)
抗原
See all KIT 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This MAb recognizes a protein of 145kDa, identified as CD117/p145kit. It is found on a wide variety of tumor cells including follicular and papillary carcinoma of thyroid, adenocarcinomas from endometrium, lung, ovary, pancreas, and breast as well as malignant melanoma, endodermal sinus tumor, and small cell carcinoma. However, anti-CD117 has been particularly useful in differentiating gastrointestinal stromal tumors from Kaposi's sarcoma, tumors of smooth muscle origin, fibromatosis, and neural tumors of the GI tract. Anti-CD117 is also useful in recognizing myeloblasts in bone marrow biopsy and clot section.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant human CD117 protein
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亚型
- IgG1 kappa
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anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 350-440) antibody
KIT 适用: 人, 小鼠, 大鼠 FACS, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 321-520) antibodyKIT 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 343-527) antibodyKIT 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mast/stem Cell Growth Factor Receptor (KIT) (pTyr721) antibodyKIT 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mast/stem Cell Growth Factor Receptor (KIT) (pTyr703) antibodyKIT 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 546-976) antibodyKIT 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2E3 unconjugated
anti-Mast/stem Cell Growth Factor Receptor (KIT) (Internal Region) antibodyVerified KIT 适用: 人 WB, FACS, ELISA, IHC, IF 宿主: 山羊 Polyclonal unconjugated
anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 25-295) antibodyKIT 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Mast/stem Cell Growth Factor Receptor (KIT) antibody (FITC)KIT 适用: 人, Cow, Non-Human Primate FACS 宿主: 小鼠 Monoclonal 104D2 FITC
anti-Mast/stem Cell Growth Factor Receptor (KIT) antibodyKIT 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 1C5 unconjugated
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应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 1 mM EDTA buffer, pH 9.5, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
Positive_Control: Gastrointestinal Stromal Tumor (GIST) or testicular germ cell tumor. Melanocytes in the basal layer of the epidermis and mast cells in the dermis of normal skin.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- KIT (Mast/stem Cell Growth Factor Receptor (KIT))
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别名
- KIT
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背景
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P145, Steel Factor Receptor, Stem Cell Factor Receptor (SCF-Receptor), Mast Cell Growth Factor Receptor,CD117 / c-Kit (Marker for Gastrointestinal Stromal Tumors)
Cellular localisation: Cell Surface and Cytoplasmic -
分子量
- ~145kDa
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基因ID
- 3815, 479754
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UniProt
- P10721
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity
抗原
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