FAF1 抗体
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北京 101111
Quick Overview for FAF1 抗体 (ABIN6937211)
抗原
See all FAF1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- In contrast to growth factors which promote cell proliferation, FAS ligand (FAS-L) and the tumor necrosis factors (TNFs) rapidly induce apoptosis. Cellular response to FAS-L and TNF is mediated by structurally related receptors containing a conserved 'death domain' and belonging to the TNF receptor superfamily. TRADD, FADD and RIP are FAS/TNF-RI interacting proteins that contain a death domain homologous region (DDH). TRADD (TNF-RI-associated death domain) and FADD (FAS-associated death domain) associate with the death domains of both FAS and TNF-RI via their DDH regions, while RIP associates exclusively with FAS. An additional FAS interacting protein designated FAF1, for FAS-associated protein factor-1, binds with the cytoplasmic tail of wildtype but not LPR mutant FAS. When overexpressed in cells, FAF1 enhances the efficiency of FAS-mediated apoptosis. In contrast to TRADD, FADD and RIP, FAF1 lacks a DDH and cannot induce apoptosis independently of FAS activation.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant human full-length FAF1 protein
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亚型
- IgG2b kappa
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anti-Fas (TNFRSF6) Associated Factor 1 (FAF1) antibody
FAF1 适用: 人 WB, IHC (f) 宿主: 小鼠 Monoclonal CPTC-FAF1-2 unconjugated
anti-Fas (TNFRSF6) Associated Factor 1 (FAF1) antibodyKD Validated FAF1 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 24GB8245 unconjugated
anti-Fas (TNFRSF6) Associated Factor 1 (FAF1) (AA 551-650) antibodyFAF1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1A10 unconjugated
anti-Fas (TNFRSF6) Associated Factor 1 (FAF1) (AA 1-650) antibodyFAF1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Fas (TNFRSF6) Associated Factor 1 (FAF1) (AA 1-650) antibodyFAF1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Fas (TNFRSF6) Associated Factor 1 (FAF1) (AA 551-650) antibodyFAF1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Fas (TNFRSF6) Associated Factor 1 (FAF1) (AA 490-629) antibodyFAF1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fas (TNFRSF6) Associated Factor 1 (FAF1) (C-Term) antibodyFAF1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fas (TNFRSF6) Associated Factor 1 (FAF1) antibodyFAF1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Fas (TNFRSF6) Associated Factor 1 (FAF1) (AA 1-280) antibodyFAF1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: Western Blot (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: HEK293, MCF-7, HeLa whole cell lysate. Human testis, prostate, breast carcinoma or colon carcinoma.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- FAF1 (Fas (TNFRSF6) Associated Factor 1 (FAF1))
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别名
- FAF1
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背景
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CGI-03, FAS-associated factor 1, HFAF1s, UBX domain-containing protein 12, UBX domain-containing protein 3A,Fas (TNFRSF6) associated factor 1
Cellular localisation: Nucleus. -
分子量
- 75-80kDa
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基因ID
- 11124, 530402
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UniProt
- Q9UNN5
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途径
- Maintenance of Protein Location
抗原
-
