Desmocollin 2 抗体 (Extracellular Domain)
Quick Overview for Desmocollin 2 抗体 (Extracellular Domain) (ABIN6937104)
抗原
See all Desmocollin 2 (DSC2) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- Extracellular Domain
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特异性
- Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. The desmosome is subdivided into two regions. The plaque region lies adjacent to the plasma, and is believed to contain molecules that attach the intermediate filament cytoskeleton to the desmosome. The core region is composed of transmembrane glycoproteins that are thought to mediate cell-cell adhesion. Desmogleins and desmocollins are the main desmosomal transmembrane proteins. These desmosomal glycoproteins belong to the members of the cadherin family of adhesion molecules. Three different isoforms of both desmogleins and desmocollins have been identified, named as desmoglein 1-3 and desmocollins. Desmosomal cadherins showed differentiation-specific expression in the human epidermis, although the functional significance of this differential expression is not fully understood. Desmocollin-1 can be found in the upper layers. The expression of desmocollin-2 varies in the basal and suprabasal layers. And desmocollin-3 is expressed more evenly throughout the suprabasal layers.
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交叉反应 （详细）
- Human. Mouse. Rat.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Human desmocollin-2 extracellular domain
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亚型
- IgG1 kappa
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anti-Desmocollin 2 (DSC2) (AA 444-534) antibody
DSC2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F2 unconjugated
anti-Desmocollin 2 (DSC2) (Extracellular Domain) antibodyDSC2 适用: 人, 小鼠, 大鼠 WB, IHC, IF, FACS, StM 宿主: 小鼠 Monoclonal 7G6 unconjugated
anti-Desmocollin 2 (DSC2) antibodyDSC2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Desmocollin 2 (DSC2) (AA 1-847) antibodyDSC2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Desmocollin 2 (DSC2) antibodyDSC2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Desmocollin 2 (DSC2) (AA 520-690) antibodyDSC2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Desmocollin 2 (DSC2) (AA 520-690) antibodyDSC2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Desmocollin 2 (DSC2) (AA 136-471) antibodyDSC2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Desmocollin 2 (DSC2) (AA 1-847) antibodyDSC2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Desmocollin 2 (DSC2) antibodyDSC2 适用: 人, 小鼠, 大鼠 ELISA, Coat 宿主: 小鼠 Monoclonal rDSC2-3437 unconjugated Recombinant Antibody
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应用备注
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Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
Positive_Control: HeLa cells. Skin tissue.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- Desmocollin 2 (DSC2)
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别名
- DSC2
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背景
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ARVD11, Cadherin family member 2, CDHF2, Desmocollin-2, Desmocollin-3, Desmosomal glycoprotein II and III, Desmosomal glycoprotein II, Desmosomal glycoprotein III, DG2, DGII/III, DSC2, DSC3,Desmocollin-2/3
Cellular localisation: Cell surface -
分子量
- 110kDa (DSC2), 100kDa (DSC3)
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基因ID
- 1824, 95612
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UniProt
- Q02487
抗原
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