Decorin 抗体 (AA 212-336)
Quick Overview for Decorin 抗体 (AA 212-336) (ABIN6937086)
抗原
See all Decorin (DCN) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 212-336
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特异性
- Decorin is a small leucine-rich proteoglycan (SLRP) family member that consists of a glycosaminoglycan chain-containing core protein. The core protein contains ten leucine rich repeats that contain sites for glycosylation, flanked by disulfide bond stabilizing loops. Decorin binds to Collagen Type I, II and IV in vivo and promotes the formation of fibers with variations in stability and solubility. The Decorin core protein binds to growth factors, intercellular matrix molecules, such as Fibronectin and Thrombospondin, and to the Decorin endocytosis receptor. Decorin binds to and inhibits TGFi² and is a direct or indirect negative modulator of TGFi² synthesis. Inhibition of Decorin core protein gene expression by the combination of IFN-i³ and TNFi± may contribute to cartilage destruction that is characteristic of inflammatory joint diseases. The human Decorin gene maps to chromosome 12q21.33 and encodes a 359 amino acid protein.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant human Decorin protein fragment (aa212-336) (exact sequence is proprietary)
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亚型
- IgG2b kappa
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anti-Decorin (DCN) (AA 31-359) antibody
DCN 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Decorin (DCN) (AA 1-359) antibodyDCN 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3H4-1F4 unconjugated
anti-Decorin (DCN) (AA 263-324) antibodyDCN 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 5E8E7 unconjugated
anti-Decorin (DCN) (Internal Region) antibodyDCN 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Decorin (DCN) antibodyDCN 适用: 人 WB, IP, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Decorin (DCN) (AA 31-359) antibodyDCN 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Decorin (DCN) (AA 122-150) antibodyDCN 适用: 人, 小鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB19595 unconjugated
anti-Decorin (DCN) (AA 31-359) antibodyDCN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Decorin (DCN) (AA 212-336) antibodyDCN 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal DCN-3523 unconjugated
anti-Decorin (DCN) antibodyDCN 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: Human prostate or skin tissue (IHC).
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- Decorin (DCN)
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别名
- DCN
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背景
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Bone proteoglycan II, CSCD, Dermatan sulphate proteoglycans II (DSPG2), PG40, PGII, PGS2, Proteoglycan core protein, SLRR1B, Small leucine rich protein 1B,Decorin
Cellular localisation: Secreted. -
分子量
- 43kDa
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基因ID
- 1634, 728830
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UniProt
- P07585
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途径
- Glycosaminoglycan Metabolic Process
抗原
-
