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BRCA1 抗体 (AA 445-620)

Name: BRCA1 抗体 (AA 445-620)
Brand: antibodies-online
SKU: ABIN6936512
Availability: OutOfStock

BRCA1 适用: 人 IHC (f) 宿主: 小鼠 Monoclonal BRCA1-1398 unconjugated

产品编号 ABIN6936512

发货至: 中国

Datasheet as PDF

抗原 See all BRCA1 抗体

BRCA1 (Breast Cancer 1 (BRCA1))
抗原表位
20

18

15

15

14

11

10

9

8

7

6

5

5

4

3

3

3

3

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 445-620
适用
188

36

25

3

2

1

1

1
人
宿主
161

33

2
小鼠
Compatible Secondaries
克隆类型
165

31
单克隆
标记
89

18

9

7

7

7

7

7

7

7

3

3

3

3

3

2

2

2

2

2

2

2

2
This BRCA1 antibody is un-conjugated
应用范围
124

67

42

41

39

37

27

22

21

12

11

10

9

8

3

2

2

2

1

1
Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

特异性

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40 % of inherited breast cancers and more than 80 % of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

交叉反应（详细）

Human.

纯化方法

1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

免疫原

Recombinant human BRCA1 protein fragment (around aa445-620) (exact sequence is proprietary)

克隆位点

BRCA1-1398

亚型

IgG1 kappa

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anti-Breast Cancer 1 (BRCA1) (AA 445-620) antibody
BRCA1 适用: 人 IHC, ISt, StM 宿主: 小鼠 Monoclonal BRCA1-1398 unconjugated

应用备注

Known_Application: Immunohistochemistry (Formalin-fixed) (2-5 μg/mL for 60 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: A431 or HeLa cells. Breast, Ovarian or Renal Cell Carcinoma.

限制

仅限研究用
浓度

1.0 mg/mL

缓冲液

Prepared in 10 mM PBS, WITHOUT BSA and Azide.

储存液

Azide free

储存条件

-20 °C,-80 °C

储存方法

Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

有效期

24 months
抗原

BRCA1 (Breast Cancer 1 (BRCA1))

别名

BRCA1 (BRCA1 产品)

别名

BRCAI antibody, BRCC1 antibody, BROVCA1 antibody, IRIS antibody, PNCA4 antibody, PPP1R53 antibody, PSCP antibody, RNF53 antibody, iris antibody, pscp antibody, brcai antibody, brcc1 antibody, rnf53 antibody, brca1 antibody, BRCA1 antibody, LOC100224649 antibody, BRCA1, DNA repair associated antibody, breast cancer 1 antibody, breast cancer 1, early onset antibody, breast cancer 1 L homeolog antibody, BRCA1 antibody, brca1 antibody, LOC755086 antibody, Brca1 antibody, brca1.L antibody

背景

BRCA1, Breast and ovarian cancer susceptibility protein 1, Breast Cancer 1 Early Onset, Breast cancer type 1 susceptibility protein, BROVCA1, IRIS, PNCA4, PPP1R53, Protein phosphatase 1 regulatory subunit 53, PSCP, RING finger protein 53, RNF53,BRCA1 (Breast Marker)
Cellular localisation: Cytoplasmic and Nuclear

分子量

220kDa

基因ID

672, 194143

UniProt

P38398

途径

Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus