CD63 抗体 (AA 101-200)
Quick Overview for CD63 抗体 (AA 101-200) (ABIN687742)
抗原
See all CD63 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
 - AA 101-200
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交叉反应
 - 人, 小鼠
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纯化方法
 - Purified by Protein A.
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免疫原
 - KLH conjugated synthetic peptide derived from human CD63
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亚型
 - IgG
 
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应用备注
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                        WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - 
                                            
限制
 - 仅限研究用
 
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状态
 - Liquid
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浓度
 - 1 μg/μL
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缓冲液
 - 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
 - ProClin
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注意事项
 - This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
 - 4 °C,-20 °C
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储存方法
 - Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
 - 12 months
 
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                                            : "Bovine Milk-Derived Exosomes as a Drug Delivery Vehicle for miRNA-Based Therapy."    in: International journal of molecular sciences, Vol. 22, Issue 3, (2021)         (PubMed).        
: "Highly potent intracellular membrane-associated Aβ seeds." in: Scientific reports, Vol. 6, pp. 28125, (2016) (PubMed).
: "Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity." in: Cell discovery, Vol. 2, pp. 16015, (2016) (PubMed).
: "Microfluidic compartments with sensing microbeads for dynamic monitoring of cytokine and exosome release from single cells." in: The Analyst, (2015) (PubMed).
 
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                                            : "Bovine Milk-Derived Exosomes as a Drug Delivery Vehicle for miRNA-Based Therapy."    in: International journal of molecular sciences, Vol. 22, Issue 3, (2021)         (PubMed).        
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- CD63
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别名
 - CD63/MLA1
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背景
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Synonyms: MLA1, ME491, LAMP-3, OMA81H, TSPAN3, CD63 antigen, Granulophysin, Lysosomal-associated membrane protein 3, Melanoma-associated antigen ME491, Ocular melanoma-associated antigen, Tetraspanin-3, Tspan-3, CD63
Background: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
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基因ID
 - 967
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UniProt
 - P08962
 
抗原
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