K-RAS 抗体
Quick Overview for K-RAS 抗体 (ABIN687622)
抗原
See all K-RAS (KRAS) 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人, 大鼠
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预测反应
- Mouse,Dog,Cow,Sheep,Pig,Horse
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human Pan-ras
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亚型
- IgG
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anti-GTPase Kras (KRAS) (AA 1-188) antibody
KRAS 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3B10-2F2 unconjugated
anti-GTPase Kras (KRAS) (AA 16-125) antibodyKRAS 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4F3 unconjugated
anti-GTPase Kras (KRAS) (AA 146-174) antibodyKRAS 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-GTPase Kras (KRAS) (AA 25-130) antibodyKRAS 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-GTPase Kras (KRAS) (AA 2-168) antibodyKRAS 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-GTPase Kras (KRAS) (N-Term) antibodyKRAS 适用: 人, 大鼠, 小鼠, 犬, 斑马鱼, 兔, 马, 豚鼠, Cow, Drosophila melanogaster, Pig, Bat, 小鸡, 非洲爪蟾, Hamster, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-GTPase Kras (KRAS) (pSer89) antibodyKRAS 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-GTPase Kras (KRAS) (N-Term) antibodyKRAS 适用: 人, 大鼠, 小鼠, 犬, 斑马鱼, 兔, 马, 豚鼠, Cow, Saccharomyces cerevisiae WB 宿主: 兔 Polyclonal unconjugated
anti-GTPase Kras (KRAS) (AA 1-189) antibodyKRAS 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-GTPase Kras (KRAS) (AA 1-188) antibodyKRAS 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E4-1B10 unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- K-RAS (KRAS) (GTPase Kras (KRAS))
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别名
- GTPase Kras
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背景
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Synonyms: K-Ras, P21 protein, p21ras, H-Ras-1, c-H-ras, N-Ras.
Background: RAS superfamily comprises around 50 related genes encoding GTP-binding domain (G-proteins) involved in signal transduction. The main genes are HRAS, NRAS and KRAS. Ras proteins are membrane-bound GTPases. The inactive form is GDP-bound. They are activated by ligand-binding receptor tyrosine kinases such as EGFR, PDGFR, colony-stimulating factor and fibroblast growth factor. These kinases transiently convert RAS-GDP to RAS-GTP, the active form of RAS. Single amino acid substitutions can activate RAS making it highly oncogenic. Such mutations generally reduce the GTPase activity of RAS, prolonging it in its active GTP-bound form. The consequence of this is sustained activation of the RAF1-MAPK signalling pathway. RAS mutations are found in 10-15 % of tumours. A high incidence of RAS mutations is found in pancreatic cancers.
抗原
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