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IFI16 抗体 (AA 201-350) (HRP)

This anti-IFI16 antibody is a 兔 多克隆 antibody detecting IFI16 in WB, ELISA, IHC (p) 和 IHC (fro). Suitable for 人.
产品编号 ABIN687046
发货至: 中国

Quick Overview for IFI16 抗体 (AA 201-350) (HRP) (ABIN687046)

抗原

See all IFI16 抗体
IFI16 (Interferon, gamma-Inducible Protein 16 (IFI16))

适用

  • 35
  • 3
  • 2

宿主

  • 30
  • 5

克隆类型

  • 32
  • 3
多克隆

标记

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  • 1
  • 1
  • 1
  • 1
  • 1
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  • 1
  • 1
This IFI16 antibody is conjugated to HRP

应用范围

  • 35
  • 13
  • 13
  • 12
  • 5
  • 5
  • 4
  • 4
  • 3
  • 2
  • 2
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • 抗原表位

    • 14
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 201-350

    交叉反应

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human IFI16

    亚型

    IgG
  • 应用备注

    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    注意事项

    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    IFI16 (Interferon, gamma-Inducible Protein 16 (IFI16))

    别名

    I16/MNDA

    背景

    Synonyms: Gamma-interferon-inducible protein i16, Interferon-inducible myeloid dferentiation transcriptional activator, A730048F03, D3, D3cDNA, i-d3, I16, I16B, I204, I205, i205a, i205b, NGIP1, MGC9466, Mnda, p204, PYHIN2.

    Background: Interferon (IFN) Inducible 16 (IFI16) protein belongs to a family of HIN 200 human and mouse proteins. IFI16 is a nuclear protein comtaining regulatory domains such as DNA binding domain, transcriptional regulatory domain and DAPIN/PAAD domain. IFI16 has three isotypes A, B, and C (85-95 kDa), which arise as a result of mRNA alternative splicing. All are phosphorylated on serine and threonine residues and can homo and heterodimerize. Expression is restricted to the nuclei of hematopoietic cells, fibroblasts and epithelial cells. IFI16 expression in hematopoietic cells of myeloid lineage is tightly regulated and highly induced in the differentiation and proliferation of the cell. Due to its localization in the nucleus, regulation of protein expression, and ability to bind DNA, it is assumed that IFI16 has a role in transcription regulation of cell differentiation. In addition, it was found that IFI16 can act as a transcriptional repressor and is involved in regulation and activation of p53 in cancer cells.

    基因ID

    3428

    途径

    Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Autophagy, Inflammasome
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