DDIT3 抗体 (AA 75-168) (FITC)
Quick Overview for DDIT3 抗体 (AA 75-168) (FITC) (ABIN685454)
抗原
See all DDIT3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 75-168
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human DDIT3
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亚型
- IgG
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anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (C-Term) antibody
DDIT3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (AA 1-169) antibodyDDIT3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (N-Term) antibodyDDIT3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (pSer30) antibodyDDIT3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (N-Term) antibodyDDIT3 适用: 人, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (AA 120-149), (C-Term) antibodyDDIT3 适用: 人, 小鼠 WB, IF, FACS 宿主: 兔 Polyclonal RB13788 unconjugated
anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (AA 1-169) antibodyDDIT3 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (Ser301) antibodyDDIT3 适用: 人, 小鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (AA 1-90) antibodyDDIT3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G3 unconjugated
anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (AA 75-168) antibodyDDIT3 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- DDIT3 (DNA-Damage-Inducible Transcript 3 (DDIT3))
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别名
- GADD153/DDIT3
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背景
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Synonyms: CHOP, CEBPZ, CHOP1, CHOP-1, GADD153, DNA damage-inducible transcript 3 protein, DDIT-3, C/EBP zeta, C/EBP-homologous protein, C/EBP-homologous protein 1, CCAAT/enhancer-binding protein homologous protein, Growth arrest and DNA damage-inducible protein GADD153, DDIT3
Background: Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF1B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates, expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
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基因ID
- 1649
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UniProt
- P35638
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途径
- Regulation of Muscle Cell Differentiation, ER-Nucleus Signaling, Skeletal Muscle Fiber Development, Cell RedoxHomeostasis
抗原
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