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DDIT3 抗体 (AA 75-168)

Name: DDIT3 抗体 (AA 75-168)
SKU: ABIN685447
Availability: OutOfStock

This anti-DDIT3 antibody is a 兔多克隆 antibody detecting DDIT3 in WB, ELISA, FACS, IHC (p), IF (cc), IF (p) 和 IHC (fro). Suitable for 人, 小鼠和大鼠. This Primary Antibody has been cited in 2+ publications.

Formalin-fixed and paraffin embedded rat brain labeled with Anti-GADD153 Polyclonal Antibody, Unconjugated (ABIN685447) at 1:200 followed by conjugation to the secondary antibody and DAB staining. (DDIT3 抗体 (AA 75-168))

IHC

1 image

(2 references)

产品编号 ABIN685447

发货至: 中国

Datasheet as PDF

Quick Overview for DDIT3 抗体 (AA 75-168) (ABIN685447)

抗原

See all DDIT3 抗体

DDIT3 (DNA-Damage-Inducible Transcript 3 (DDIT3))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This DDIT3 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Discover our top product DDIT3 Primary Antibody

抗原表位
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1
AA 75-168

交叉反应

人, 小鼠, 大鼠

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human DDIT3

亚型

IgG
anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (C-Term) antibody
DDIT3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (AA 1-169) antibody
DDIT3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (N-Term) antibody
DDIT3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (pSer30) antibody
DDIT3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (N-Term) antibody
DDIT3 适用: 人, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (AA 120-149), (C-Term) antibody
DDIT3 适用: 人, 小鼠 WB, IF, FACS 宿主: 兔 Polyclonal RB13788 unconjugated

anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (AA 1-169) antibody
DDIT3 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (Ser301) antibody
DDIT3 适用: 人, 小鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (AA 1-90) antibody
DDIT3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G3 unconjugated

anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (AA 1-90) antibody
DDIT3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Ding, Zou, Li, Tian, Abdelalim, Du, She, Wang, Tan, Wang, Chen, Lv, Chang: "Study of histopathological and molecular changes of rat kidney under simulated weightlessness and resistance training protective effect." in: PLoS ONE, Vol. 6, Issue 5, pp. e20008, (2011) (PubMed).

Du, Zhou, Jia, Huang: "SelK is a novel ER stress-regulated protein and protects HepG2 cells from ER stress agent-induced apoptosis." in: Archives of biochemistry and biophysics, Vol. 502, Issue 2, pp. 137-43, (2010) (PubMed).
抗原

DDIT3 (DNA-Damage-Inducible Transcript 3 (DDIT3))

别名

GADD153/DDIT3

背景

Synonyms: CHOP, CEBPZ, CHOP1, CHOP-1, GADD153, DNA damage-inducible transcript 3 protein, DDIT-3, C/EBP zeta, C/EBP-homologous protein, C/EBP-homologous protein 1, CCAAT/enhancer-binding protein homologous protein, Growth arrest and DNA damage-inducible protein GADD153, DDIT3
Background: Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF1B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates, expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.

基因ID

1649

UniProt

P35638

途径

Regulation of Muscle Cell Differentiation, ER-Nucleus Signaling, Skeletal Muscle Fiber Development, Cell RedoxHomeostasis