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Clusterin 抗体 (AA 331-449)

This anti-Clusterin antibody is a 兔 多克隆 antibody detecting Clusterin in ELISA, IHC (p), FACS, IHC (fro), IF (cc) 和 IF (p). Suitable for 人, 大鼠 和 小鼠. This Primary Antibody has been cited in 2+ publications.
产品编号 ABIN685342
发货至: 中国

Quick Overview for Clusterin 抗体 (AA 331-449) (ABIN685342)

抗原

See all Clusterin (CLU) 抗体
Clusterin (CLU)

适用

  • 101
  • 33
  • 33
  • 24
  • 24
  • 10
  • 3
  • 3
  • 2
  • 1
人, 大鼠, 小鼠

宿主

  • 115
  • 63
  • 9
  • 5
  • 2
  • 2
  • 1

克隆类型

  • 122
  • 71
  • 2
多克隆

标记

  • 125
  • 32
  • 22
  • 5
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This Clusterin antibody is un-conjugated

应用范围

  • 165
  • 124
  • 72
  • 53
  • 50
  • 28
  • 25
  • 14
  • 8
  • 6
  • 5
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • 抗原表位

    • 13
    • 12
    • 12
    • 10
    • 7
    • 7
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 331-449

    交叉反应

    人, 小鼠, 大鼠

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human Apolipoprotein J

    亚型

    IgG
  • 应用备注

    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    有效期

    12 months
  • Keck, Androsova, Gualtieri, Walker, von Rüden, Russmann, Deeg, Hauck, Krause, Potschka: "A systems level analysis of epileptogenesis-associated proteome alterations." in: Neurobiology of disease, Vol. 105, pp. 164-178, (2017) (PubMed).

    Yu, Chen, Wang, Zhou, Luo, Xu, Shen, Yin, Tao, Xiao, Xiao, Lü, Wang: "Time-dependent decrease of clusterin as a potential cerebrospinal fluid biomarker for drug-resistant epilepsy." in: Journal of molecular neuroscience : MN, Vol. 54, Issue 1, pp. 1-9, (2014) (PubMed).

  • 抗原

    Clusterin (CLU)

    别名

    Apolipoprotein J

    背景

    Synonyms: CLI, AAG4, APOJ, CLU1, CLU2, KUB1, SGP2, APO-J, SGP-2, SP-4, TRPM2, TRPM-2, NA1/NA2, Clusterin, Aging-associated gene 4 protein, Apolipoprotein J, Complement cytolysis inhibitor, Complement-associated protein SP-4,4, Ku7-binding protein 1, Testosterone-repressed prostate message 2, CLU

    Background: Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC7. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.

    基因ID

    1191

    UniProt

    P10909

    途径

    Apoptosis, Negative Regulation of intrinsic apoptotic Signaling
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