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Clusterin 抗体 (AA 331-449)

Name: Clusterin 抗体 (AA 331-449)
SKU: ABIN685342
Availability: OutOfStock

This anti-Clusterin antibody is a 兔多克隆 antibody detecting Clusterin in ELISA, IHC (p), FACS, IHC (fro), IF (cc) 和 IF (p). Suitable for 人, 大鼠和小鼠. This Primary Antibody has been cited in 2+ publications.

Mouse liver lysates probed with Rabbit Anti-Apolipoprotein J Polyclonal Antibody, Unconjugated at 1:500 for 90 min at 37˚C. (Clusterin 抗体 (AA 331-449))

Formalin-fixed and paraffin embedded tumor tissue labeled with Anti-APOJ/Clusterin-? (Clusterin 抗体 (AA 331-449))

IHC

Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-APOJ/Clusterin Polyclonal Antibody, Unconjugated (ABIN685342) at 1:200 followed by conjugation to the secondary antibody and DAB staining (Clusterin 抗体 (AA 331-449))

IHC

Lane 1: mouse brain lysates Lane 2: human colon carcinoma lysates probed with Anti APOJ/CLUSTERIN Polyclonal Antibody, Unconjugated (ABIN685342) at 1:200 in 4C. (Clusterin 抗体 (AA 331-449))

SDS

Formalin-fixed and paraffin embedded rat testis labeled with Anti-APOJ/Clusterin Polyclonal Antibody, Unconjugated (ABIN685342) at 1:200 followed by conjugation to the secondary antibody and DAB staining (Clusterin 抗体 (AA 331-449))

IHC

5 images

(2 references)

产品编号 ABIN685342

发货至: 中国

Quick Overview for Clusterin 抗体 (AA 331-449) (ABIN685342)

抗原

See all Clusterin (CLU) 抗体

Clusterin (CLU)

适用

人, 大鼠, 小鼠

宿主

兔

克隆类型

多克隆

标记

This Clusterin antibody is un-conjugated

应用范围

ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

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AA 331-449

交叉反应

人, 小鼠, 大鼠

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human Apolipoprotein J

亚型

IgG
anti-Clusterin (CLU) (AA 229-446) antibody
CLU 适用: Pig WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Clusterin (CLU) (AA 227-448) antibody
CLU 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Clusterin (CLU) (AA 228-449) antibody
CLU 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Clusterin (CLU) (AA 226-447) antibody
CLU 适用: 兔 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C10 unconjugated

anti-Clusterin (CLU) (C-Term) antibody
Verified CLU 适用: 人 WB, IHC, ELISA, IF 宿主: 山羊 Polyclonal unconjugated

anti-Clusterin (CLU) (AA 23-120) antibody
CLU 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Clusterin (CLU) (AA 227-447) antibody
CLU 适用: 大鼠 WB, IHC 宿主: 小鼠 Monoclonal C1 unconjugated

anti-Clusterin (CLU) (C-Term) antibody
Verified CLU 适用: 大鼠, 小鼠 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated

anti-Clusterin (CLU) (AA 402-501) antibody
CLU 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A11 unconjugated

anti-Clusterin (CLU) (Internal Region) antibody
CLU 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Keck, Androsova, Gualtieri, Walker, von Rüden, Russmann, Deeg, Hauck, Krause, Potschka: "A systems level analysis of epileptogenesis-associated proteome alterations." in: Neurobiology of disease, Vol. 105, pp. 164-178, (2017) (PubMed).

Yu, Chen, Wang, Zhou, Luo, Xu, Shen, Yin, Tao, Xiao, Xiao, Lü, Wang: "Time-dependent decrease of clusterin as a potential cerebrospinal fluid biomarker for drug-resistant epilepsy." in: Journal of molecular neuroscience : MN, Vol. 54, Issue 1, pp. 1-9, (2014) (PubMed).
抗原

Clusterin (CLU)

别名

Apolipoprotein J

背景

Synonyms: CLI, AAG4, APOJ, CLU1, CLU2, KUB1, SGP2, APO-J, SGP-2, SP-4, TRPM2, TRPM-2, NA1/NA2, Clusterin, Aging-associated gene 4 protein, Apolipoprotein J, Complement cytolysis inhibitor, Complement-associated protein SP-4,4, Ku7-binding protein 1, Testosterone-repressed prostate message 2, CLU
Background: Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC7. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.

基因ID

1191

UniProt

P10909

途径

Apoptosis, Negative Regulation of intrinsic apoptotic Signaling