beta Catenin 抗体 (pSer45, pThr41) (Cy3)
Quick Overview for beta Catenin 抗体 (pSer45, pThr41) (Cy3) (ABIN683956)
抗原
See all beta Catenin (CATNB) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer45, pThr41
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特异性
- This phophorylation site is homologous to that of Thr41 + Ser45 in Mouse and Rat.
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交叉反应
- 人, 大鼠
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预测反应
- Mouse,Cow,Pig,Horse,Chicken,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic phosphopeptide derived from human Beta-Catenin around the phosphorylation site of Thr41/Ser45
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亚型
- IgG
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anti-Catenin, beta (CATNB) (pSer33), (pSer37) antibody
CATNB 适用: 人, 小鼠, 大鼠 WB, FACS, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Catenin, beta (CATNB) (AA 661-781) antibodyCATNB 适用: 人, 小鼠, 大鼠, Pig, 斑马鱼 WB, FACS, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Catenin, beta (CATNB) (C-Term) antibodyCATNB 适用: 人, 小鼠, 大鼠, 小鸡, Cow, 犬, Pig, 兔, 绵羊, 猴, Hamster, Avian, Cat, 驴, 山羊, 豚鼠, 马 WB, IF 宿主: 山羊 Polyclonal unconjugated
anti-Catenin, beta (CATNB) (C-Term) antibodyCATNB 适用: 人, 斑马鱼 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Catenin, beta (CATNB) (pSer33), (pSer37), (pThr41) antibodyCATNB 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Catenin, beta (CATNB) (AA 439-675) antibodyCATNB 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Catenin, beta (CATNB) (AA 439-675) antibodyCATNB 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C11 unconjugated
anti-Catenin, beta (CATNB) antibodyCATNB 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 小鼠 Monoclonal 4A3H3 unconjugated
anti-Catenin, beta (CATNB) antibodyCATNB 适用: 人, 小鼠, Hamster WB, IP, ICC, ICFC 宿主: 小鼠 Monoclonal EM-22 unconjugated
anti-Catenin, beta (CATNB) (AA 764-781) antibodyCATNB 适用: 人, 小鼠, 大鼠 WB, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- beta Catenin (CATNB) (Catenin, beta (CATNB))
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别名
- Beta Catenin +
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背景
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Synonyms: CTNNB, MRD19, armadillo, Catenin beta-1, Beta-catenin, CTNNB1, OK/SW-cl.35, PRO2286
Background: Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.
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基因ID
- 1499
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UniProt
- P35222
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途径
- Peptide Hormone Metabolism
抗原
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