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FLT4 抗体 (AA 901-1000)

Name: FLT4 抗体 (AA 901-1000)
SKU: ABIN678578
Availability: OutOfStock

FLT4 适用: 人, 小鼠, Cow ELISA, FACS, IHC (p), IF (cc), IF (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

Formalin-fixed and paraffin embedded human gastric cancer labeled with Anti-VEGFR3 Polyclonal Antibody, Unconjugated (ABIN678578) at 1:200 followed by conjugation to the secondary antibody and DAB staining (FLT4 抗体 (AA 901-1000))

IHC

A549 cells probed with VEGFR3 Polyclonal Antibody, Unconjugated at 1:100 for 30 minutes followed by incubation with a conjugated secondary (PE conjugated) (green) for 30 minutes compared to control cells (blue), secondary only (light blue) and isotype control (orange). (FLT4 抗体 (AA 901-1000))

FACS

3 images

(3 references)

产品编号 ABIN678578

发货至: 中国

Datasheet as PDF

抗原 See all FLT4 抗体

FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))
抗原表位
14

13

5

4

4

4

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 901-1000
适用
72

42

14

9
人, 小鼠, Cow
宿主
63

18

7

2

1
兔
Compatible Secondaries
克隆类型
64

27
多克隆
标记
50

7

6

4

3

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This FLT4 antibody is un-conjugated
应用范围
43

35

28

25

13

11

11

9

8

5

5

5

2

1

1

1
ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

交叉反应

Cow, 人, 小鼠

预测反应

Rat

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from Mouse VEGFR-3

亚型

IgG

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FLT4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5B5 unconjugated

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FLT4 适用: 人 IHC (p) 宿主: 小鼠 Monoclonal 8C1 unconjugated

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FLT4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

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FLT4 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Fms-Related Tyrosine Kinase 4 (FLT4) (AA 34-133) antibody
FLT4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2E3 unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Wang, Wang, Li, Wu, Sun, Chen, Feng, Chen, Cai, Xu, He: "CXCL1 from tumor-associated lymphatic endothelial cells drives gastric cancer cell into lymphatic system via activating integrin β1/FAK/AKT signaling." in: Cancer letters, Vol. 385, pp. 28-38, (2016) (PubMed).

Zhuo, Jia, Song, Lu, Ding, Wang, Song, Fu, Luo: "The CXCL12-CXCR4 chemokine pathway: a novel axis regulates lymphangiogenesis." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 19, pp. 5387-98, (2012) (PubMed).

Wang, Zhou, Lin, Wang, Lin, Li: "RhGH attenuates ischemia injury of intrahepatic bile ducts relating to liver transplantation." in: The Journal of surgical research, Vol. 171, Issue 1, pp. 300-10, (2011) (PubMed).
抗原

FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))

别名

VEGFR3 (FLT4 产品)

背景

Synonyms: PCL, FLT41, LMPH1A, VEGFR3, Vascular endothelial growth factor receptor 3, VEGFR-3, Fms-like tyrosine kinase 4, FLT-4, Tyrosine-protein kinase receptor FLT4, FLT4
Background: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades, isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.

基因ID

2324

UniProt

P35916

途径

RTK signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGF Signaling