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PKD2 抗体 (AA 651-750) (Biotin)

This anti-PKD2 antibody is a Rabbit Polyclonal antibody detecting PKD2 in ELISA, IHC (p), IHC (fro). Suitable for Human, Mouse.
产品编号 ABIN678100
发货至: 中国

Quick Overview for PKD2 抗体 (AA 651-750) (Biotin) (ABIN678100)

抗原

See all PKD2 抗体
PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))

适用

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人, 小鼠

宿主

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克隆类型

  • 76
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多克隆

标记

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This PKD2 antibody is conjugated to Biotin

应用范围

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ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • 抗原表位

    • 14
    • 8
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    • 2
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    • 1
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    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    AA 651-750

    特异性

    This antibody may have a minor secondary cross-reactivity towards Polycystin 2-like protein 1 due to a 71 % non-contiguous sequence similarity in the immunogen sequence.

    交叉反应

    人, 小鼠

    预测反应

    Rat,Dog,Cow,Chicken

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human Polycystin 2

    亚型

    IgG
  • 应用备注

    IHC-P 1:200-400
    IHC-F 1:100-500

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C for 12 months.

    有效期

    12 months
  • 抗原

    PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))

    别名

    Polycystin 2

    背景

    Synonyms: PC2, PKD4, Pc-2, APKD2, TRPP2, Polycystin-2, Autosomal dominant polycystic kidney disease type II protein, Polycystic kidney disease 2 protein, Polycystwin, R48321, Transient receptor potential cation channel subfamily P member 2, PKD2

    Background: Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD1L1 in cilia to facilitate flow detection in left/right patterning (By similarity).

    基因ID

    5311

    UniProt

    Q13563

    途径

    cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity
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