PKD2 抗体 (AA 651-750) (Biotin)
Quick Overview for PKD2 抗体 (AA 651-750) (Biotin) (ABIN678100)
抗原
See all PKD2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 651-750
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特异性
- This antibody may have a minor secondary cross-reactivity towards Polycystin 2-like protein 1 due to a 71 % non-contiguous sequence similarity in the immunogen sequence.
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交叉反应
- 人, 小鼠
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预测反应
- Rat,Dog,Cow,Chicken
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human Polycystin 2
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亚型
- IgG
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anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (AA 261-360) antibody
PKD2 适用: 人 ELISA, WB, IF 宿主: 小鼠 Monoclonal 4C8 unconjugated
anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (AA 621-832) antibodyPKD2 适用: 人 ELISA, WB, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (AA 327-539) antibodyPKD2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (AA 680-968) antibodyPKD2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (pSer876) antibodyPKD2 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (AA 261-360) antibodyPKD2 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 1G3 unconjugated
anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (AA 240-410) antibodyPKD2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (AA 651-750) antibodyPKD2 适用: 人, 小鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (Internal Region) antibodyVerified PKD2 适用: 人 ELISA, WB 宿主: 山羊 Polyclonal unconjugated
anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (Tyr654) antibodyPKD2 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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IHC-P 1:200-400
IHC-F 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))
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别名
- Polycystin 2
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背景
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Synonyms: PC2, PKD4, Pc-2, APKD2, TRPP2, Polycystin-2, Autosomal dominant polycystic kidney disease type II protein, Polycystic kidney disease 2 protein, Polycystwin, R48321, Transient receptor potential cation channel subfamily P member 2, PKD2
Background: Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD1L1 in cilia to facilitate flow detection in left/right patterning (By similarity).
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基因ID
- 5311
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UniProt
- Q13563
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途径
- cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity
抗原
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