Menin 抗体 (AA 501-615) (Biotin)
Quick Overview for Menin 抗体 (AA 501-615) (Biotin) (ABIN676345)
抗原
See all Menin (MEN1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 501-615
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Dog,Cow,Pig
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human Menin
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亚型
- IgG
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应用备注
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IHC-P 1:200-400
IHC-F 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))
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别名
- Menin
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背景
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Synonyms: MEAI, SCG2, Menin, MEN1
Background: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.
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基因ID
- 4221
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UniProt
- O00255
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途径
- Chromatin Binding, Positive Regulation of Endopeptidase Activity
抗原
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