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ROCK2 抗体 (AA 1001-1300) (HRP)

This anti-ROCK2 antibody is a 兔 多克隆 antibody detecting ROCK2 in WB, ELISA, IHC (p) 和 IHC (fro). Suitable for 人, 大鼠 和 小鼠.
产品编号 ABIN673368
发货至: 中国

Quick Overview for ROCK2 抗体 (AA 1001-1300) (HRP) (ABIN673368)

抗原

See all ROCK2 抗体
ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2))

适用

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人, 大鼠, 小鼠

宿主

  • 91
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克隆类型

  • 87
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多克隆

标记

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This ROCK2 antibody is conjugated to HRP

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • 抗原表位

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    AA 1001-1300

    交叉反应

    人, 小鼠, 大鼠

    预测反应

    Rabbit

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human ROCK2

    亚型

    IgG
  • 应用备注

    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    注意事项

    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2))

    别名

    ROCK2

    背景

    Synonyms: ROCK-II, Rho-associated protein kinase 2, Rho kinase 2, Rho-associated, coiled-coil-containing protein kinase 2, Rho-associated, coiled-coil-containing protein kinase II, p164 ROCK-2, ROCK2, KIAA619

    Background: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP3, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p9RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.

    基因ID

    9475

    UniProt

    O75116

    途径

    Microtubule Dynamics, WNT signaling, Tube Formation
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