TCP1 alpha/CCTA 抗体 (AA 361-450) (FITC)
Quick Overview for TCP1 alpha/CCTA 抗体 (AA 361-450) (FITC) (ABIN672343)
抗原
See all TCP1 alpha/CCTA (TCP1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 361-450
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预测反应
- Dog,Cow,Sheep,Pig,Horse,Rabbit,Guinea Pig
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human p63 protein
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亚型
- IgG
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C/-80 °C
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储存方法
- Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles
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有效期
- 12 months
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- TCP1 alpha/CCTA (TCP1) (T-Complex 1 (TCP1))
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别名
- p63
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背景
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Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.
Subcellular location: Nucleus
Synonyms: AIS, KET, LMS, NBP, RHS, p4, p51, p63, EEC3, OFC8, p73H, p73L, SHFM4, TP53L, TP73L, p53CP, TP53CP, B(p51A), B(p51B), Tumor protein 63, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor KET, Transformation-related protein 63, TP63, Tumor protein p73-like
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基因ID
- 8626
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UniProt
- Q9H3D4
抗原
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