MEF2C 抗体
Quick Overview for MEF2C 抗体 (ABIN6719606)
抗原
See all MEF2C 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Anti-MEF2C Antibody Picoband®
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序列
- FHSPIGLTRP SPDERESPSV KRMRLSEGWA T
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-MEF2C Antibody Picoband® (ABIN6719606). Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human MEF2C, identical to the related mouse and rat sequences.
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亚型
- IgG
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anti-Myocyte Enhancer Factor 2C (MEF2C) (AA 1-125) antibody
MEF2C 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 6H2G2 unconjugated
anti-Myocyte Enhancer Factor 2C (MEF2C) antibodyMEF2C 适用: 人 WB, IHC, IF, IHC (p), ICC, IHC (fro), IP 宿主: 兔 Polyclonal unconjugated
anti-Myocyte Enhancer Factor 2C (MEF2C) antibodyMEF2C 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Myocyte Enhancer Factor 2C (MEF2C) (AA 170-380) antibodyMEF2C 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Myocyte Enhancer Factor 2C (MEF2C) (AA 365-394) antibodyMEF2C 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Myocyte Enhancer Factor 2C (MEF2C) (Ser59) antibodyMEF2C 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Myocyte Enhancer Factor 2C (MEF2C) (Ser396) antibodyMEF2C 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Myocyte Enhancer Factor 2C (MEF2C) (Ser396) antibodyMEF2C 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Myocyte Enhancer Factor 2C (MEF2C) (AA 170-380) antibodyMEF2C 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Myocyte Enhancer Factor 2C (MEF2C) (AA 170-380) antibodyMEF2C 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
1. Barbosa, A. C., Kim. M.-S., Ertunc, M., Adachi, M., Nelson, E. D., McAnally, J., Richardson, J. A., Kavalali, E. T., Monteggia, L. M., Bassel-Duby, R., Olson, E. N. MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function. Proc. Nat. Acad. Sci. 105: 9391-9396, 2008. 2. Chen, S. L., Dowhan, D. H., Hosking, B. M., Muscat, G. E. O. The steroid receptor coactivator, GRIP-1, is necessary for MEF-2C-dependent gene expression and skeletal muscle differentiation. Genes Dev. 14: 1209-1228, 2000. 3. Krainc, D., Haas, M., Ward, D. C., Lipton, S. A., Bruns, G., Leifer, D. Assignment of human myocyte-specific enhancer binding factor 2C (hMEF2C) to human chromosome 5q14 and evidence that MEF2C is evolutionarily conserved. Genomics 29: 809-811, 1995. -
说明
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Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- MEF2C (Myocyte Enhancer Factor 2C (MEF2C))
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别名
- MEF2C
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背景
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Synonyms: Myocyte-specific enhancer factor 2C , Myocyte enhancer factor 2C
Tissue Specificity: Expressed in brain and skeletal muscle.
Background: MEF2C (myocyte enhancer factor 2C), also called MADS box transcription enhancer factor 2, polypeptide C, is a protein that in humans is encoded by the MEF2C gene. MEF2C is a transcription factor in the Mef2 family. MEF2C, however, is induced late during myogenic differentiation and has a strict tissue-specific pattern of expression not seen in MEF2A or MEF2B. By fluorescence in situ hybridization, the human MEF2C is mapped to chromosome 5q14, a region with homology of synteny to the mouse location.MEF2C may be involved with maintenance of the differentiated state. Both MEF2A and Mef2c programmed similar profiles of gene expression in the heart that included genes involved in extracellular matrix remodeling, ion handling, and metabolism. NCOA2 mediates the coactivation of MEF2C-dependent transcription through interaction with the MADS box domain of MEF2C.
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分子量
- 50-65 kDa
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基因ID
- 4208
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UniProt
- Q06413
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途径
- Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, BCR Signaling
抗原
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