FRZB 抗体 (AA 49-311)
Quick Overview for FRZB 抗体 (AA 49-311) (ABIN6719567)
抗原
See all FRZB 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 49-311
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原理
- Anti-FRZB Antibody
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-FRZB Antibody (ABIN6719567). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived mouse FRZB recombinant protein (Position: N49-K311).
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亚型
- IgG
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anti-Frizzled-Related Protein (FRZB) (AA 1-325) antibody
FRZB 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Frizzled-Related Protein (FRZB) (C-Term) antibodyFRZB 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Frizzled-Related Protein (FRZB) (Middle Region) antibodyFRZB 适用: 人, 小鼠, 大鼠, 马, Cow, 犬, 豚鼠, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Frizzled-Related Protein (FRZB) (AA 166-325) antibodyFRZB 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Frizzled-Related Protein (FRZB) (AA 59-108) antibodyFRZB 适用: 人, 大鼠, 马, Cow, 豚鼠, 兔, Bat, 猴, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Frizzled-Related Protein (FRZB) (AA 102-190) antibodyFRZB 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4E5 unconjugated
anti-Frizzled-Related Protein (FRZB) (AA 102-190) antibodyFRZB 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4F7 unconjugated
anti-Frizzled-Related Protein (FRZB) (AA 102-190) antibodyFRZB 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3F4 unconjugated
anti-Frizzled-Related Protein (FRZB) (AA 216-265) antibodyFRZB 适用: 人, 小鼠, 大鼠, 马, 犬, Bat, 猴, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Frizzled-Related Protein (FRZB) (AA 166-325) antibodyFRZB 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL
ELISA, 0.1-0.5 μg/mL
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说明
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Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- FRZB (Frizzled-Related Protein (FRZB))
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别名
- Frzb
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背景
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Synonyms: Secreted frizzled-related protein 3, sFRP-3, Frezzled, Fritz, Frizzled-related protein 1, FrzB-1, Frzb, Fiz, Fre, Frzb1, Sfrp3
Tissue Specificity: Expressed in kidney, brain, testis. Weak expression in spleen and heart.
Background: FRZB is also known as FRE or OS1. The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. FRZB is a Wnt-binding protein especially important in embryonic development. It is a competitor for the cell-surface G-protein receptor Frizzled. FRZB is localized in the extracellular plasma membrane. Unlike frizzled, frzb lacks the 7 transmembrane domains normally found in G-protein-coupled receptors. It is still considered a homolog of frizzled because it contains a Cysteine Rich Domain (CRD), and because of its intracellular C-terminus which is crucial for signaling.
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分子量
- 36 kDa
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基因ID
- 20378
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UniProt
- P97401
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途径
- WNT signaling, Positive Regulation of fat Cell Differentiation
抗原
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