EPO 抗体 (AA 28-193)
Quick Overview for EPO 抗体 (AA 28-193) (ABIN6719435)
抗原
See all EPO 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 28-193
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原理
- Anti-Erythropoietin EPO Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Erythropoietin EPO Antibody (ABIN6719435). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human EPO recombinant protein (Position: A28-R193).
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亚型
- IgG
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anti-Erythropoietin (EPO) (AA 28-193) antibody
EPO 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Erythropoietin (EPO) (AA 101-193) antibodyEPO 适用: 人, 大鼠 WB, ELISA, FACS, IHC (p), IF (p), IF (cc), IHC (fro), DB 宿主: 兔 Polyclonal unconjugated
anti-Erythropoietin (EPO) (AA 28-193) antibodyEPO 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal C3 unconjugated
anti-Erythropoietin (EPO) antibodyEPO 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Erythropoietin (EPO) (AA 28-162) antibodyEPO 适用: 人 WB, IHC, ELISA, Coat, StM 宿主: 小鼠 Monoclonal EPO-1368 unconjugated
anti-Erythropoietin (EPO) (AA 28-162) antibodyEPO 适用: 人 IHC, ELISA, Coat, StM 宿主: 小鼠 Monoclonal EPO-1367 unconjugated
anti-Erythropoietin (EPO) (AA 20-48) antibodyEPO 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Erythropoietin (EPO) (AA 28-191) antibodyEPO 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Erythropoietin (EPO) antibodyEPO 适用: 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Erythropoietin (EPO) (AA 28-193) antibodyEPO 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4G7 unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL
ELISA, 0.1-0.5 μg/mL
1. Hosseini-Zare MS, Dashti-Khavidaki S, Mahdavi-Mazdeh M, Ahmadi F, Akrami S (2012). "Peripheral neuropathy response to erythropoietin in type 2 diabetic patients with mild to moderate renal failure". Clinical Neurology and Neurosurgery. 114 (6): 663-7. 2. Middleton SA, Barbone FP, Johnson DL, Thurmond RL, You Y, McMahon FJ, Jin R, Livnah O, Tullai J, Farrell FX, Goldsmith MA, Wilson IA, Jolliffe LK (1999). "Shared and unique determinants of the erythropoietin (EPO) receptor are important for binding EPO and EPO mimetic peptide". The Journal of Biological Chemistry. 274 (20): 14163-9. -
说明
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Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- EPO (Erythropoietin (EPO))
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别名
- EPO
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物质类
- Hormone
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背景
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Synonyms: Erythropoietin, Epoetin, EPO
Tissue Specificity: Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.
Background: This EPO gene encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The encoded protein is mainly synthesized in the kidney, secreted into the blood plasma, and binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow. Expression of this gene is upregulated under hypoxic conditions, in turn leading to increased erythropoiesis and enhanced oxygen-carrying capacity of the blood. Expression of this gene has also been observed in brain and in the eye, and elevated expression levels have been observed in diabetic retinopathy and ocular hypertension. Recombinant forms of the encoded protein exhibit neuroprotective activity against a variety of potential brain injuries, as well as antiapoptotic functions in several tissue types, and have been used in the treatment of anemia and to enhance the efficacy of cancer therapies.
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分子量
- 29 kDa
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基因ID
- 2056
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UniProt
- P01588
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途径
- JAK/STAT Signaling, Hormone Activity, Negative Regulation of intrinsic apoptotic Signaling, Negative Regulation of Transporter Activity
抗原
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