DOK7 抗体
Quick Overview for DOK7 抗体 (ABIN6719428)
抗原
See all DOK7 抗体适用
宿主
克隆类型
标记
应用范围
-
-
原理
- Anti-DOK7 Antibody
-
序列
- STVEERVAQE ALETLQLEKR LSLLSHAGR
-
交叉反应 （详细）
- No cross-reactivity with other proteins.
-
产品特性
- Anti-DOK7 Antibody (ABIN6719428). Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human DOK7, which shares 86.2% amino acid (aa) sequence identity with mouse DOK7.
-
亚型
- IgG
-
-
anti-Docking Protein 7 (DOK7) antibody
DOK7 适用: 人 WB, IHC, FACS, IHC (p) 宿主: 小鼠 Monoclonal 7E2 unconjugated
anti-Docking Protein 7 (DOK7) (N-Term) antibodyDOK7 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Docking Protein 7 (DOK7) (AA 416-504) antibodyDOK7 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Docking Protein 7 (DOK7) (C-Term) antibodyDOK7 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Docking Protein 7 (DOK7) antibodyDOK7 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 3C12 unconjugated
anti-Docking Protein 7 (DOK7) antibodyDOK7 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 5C6 unconjugated
anti-Docking Protein 7 (DOK7) (AA 63-320) antibodyDOK7 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Docking Protein 7 (DOK7) (AA 10-59) antibodyDOK7 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Docking Protein 7 (DOK7) (AA 21-120) antibodyDOK7 适用: 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Docking Protein 7 (DOK7) (AA 402-451) antibodyDOK7 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Western blot, 0.1-0.5 μg/mL
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL
Flow Cytometry(Fixed), 1-3 μg/1x106 cells
-
说明
-
Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
-
-
- DOK7 (Docking Protein 7 (DOK7))
-
别名
- DOK7
-
背景
-
Synonyms: Protein Dok-7, Downstream of tyrosine kinase 7, DOK7, C4orf25,
Tissue Specificity: Preferentially expressed in skeletal muscle and heart. Present in thigh muscle, diaphragm and heart but not in the liver or spleen .
Background: Dok-7 is a non-catalytic cytoplasmic adaptor protein that is expressed specifically in muscle and is essential for the formation of neuromuscular synapses. Further, Dok-7 contains pleckstrin homology (PH) and phosphotyrosine-binding (PTB) domains that are critical for Dok-7 function. It is mapped to 4p16.3. The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants.
-
分子量
- 65 kDa
-
基因ID
- 285489
-
途径
- Skeletal Muscle Fiber Development
抗原
-
