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OPTN 抗体 (AA 241-577)

This anti-OPTN antibody is a 小鼠单克隆 antibody detecting OPTN in WB 和 FACS. Suitable for 人, 小鼠和大鼠.

产品编号 ABIN6719352

发货至: 中国

Quick Overview for OPTN 抗体 (AA 241-577) (ABIN6719352)

抗原

See all OPTN 抗体

OPTN (Optineurin (OPTN))

适用

54
33
15
7
6
5
5
5
2
2
1

人, 小鼠, 大鼠

宿主

小鼠

克隆类型

单克隆

标记

33
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1

This OPTN antibody is un-conjugated

应用范围

50
14
13
13
13
12
8
7
5
3
1

Western Blotting (WB), Flow Cytometry (FACS)

克隆位点

3D8

Discover our top product OPTN Primary Antibody

抗原表位
15

7

4

3

3

2

2

2

1

1

1

1

1

1
AA 241-577

原理

Anti-Optineurin/OPTN Antibody Picoband® (monoclonal, 3D8)

交叉反应（详细）

No cross-reactivity with other proteins.

产品特性

Anti-Optineurin/OPTN Antibody Picoband® (monoclonal, 3D8) (ABIN6719352). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

E.coli-derived human Optineurin recombinant protein (Position: R241-I577). Human Optineurin shares 82% amino acid (aa) sequence identity with both mouse and rat Optineurin.

亚型

IgG2b
anti-Optineurin (OPTN) (AA 341-440) antibody
OPTN 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Optineurin (OPTN) (AA 1-300) antibody
OPTN 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Optineurin (OPTN) (AA 1-577) antibody
OPTN 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated

anti-Optineurin (OPTN) antibody
OPTN 适用: 人 WB, IP, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Optineurin (OPTN) (AA 1-577) antibody
OPTN 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated

anti-Optineurin (OPTN) (AA 575-591) antibody
OPTN 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Optineurin (OPTN) (AA 1-577) antibody
OPTN 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Optineurin (OPTN) (AA 559-575) antibody
OPTN 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Optineurin (OPTN) (AA 72-121) antibody
OPTN 适用: 人, 小鼠, 犬, 豚鼠, Cow, Pig WB 宿主: 兔 Polyclonal unconjugated

anti-Optineurin (OPTN) (C-Term) antibody
OPTN 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated

应用备注

Western blot, 0.1-0.5 μg/mL
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells
1. Johnson L, et al. Screening for OPTN mutations in a cohort of British amyotrophic lateral sclerosis patients. Neurobiol Aging, 2012 Dec. 2. Michou L, et al. Genetic association study of UCMA/GRP and OPTN genes (PDB6 locus) with Paget's disease of bone. Bone, 2012 Oct. 3. Weishaupt JH, et al. A novel optineurin truncating mutation and three glaucoma-associated missense variants in patients with familial amyotrophic lateral sclerosis in Germany.

说明

Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
抗原

OPTN (Optineurin (OPTN))

别名

OPTN

背景

Synonyms: Optineurin, E3-14.7K-interacting protein, FIP-2, Huntingtin yeast partner L, Huntingtin-interacting protein 7,HIP-7, Huntingtin-interacting protein L, NEMO-related protein, Optic neuropathy-inducing protein, Transcription factor IIIA-interacting protein, TFIIIA-IntP, OPTN, FIP2, GLC1E, HIP7, HYPL, NRP
Tissue Specificity: Present in aqueous humor of the eye. Highly expressed in trabecular meshwork. Expressed nonpigmented ciliary epithelium, retina, brain, adrenal cortex, fetus, lymphocyte, fibroblast, skeletal muscle, heart, liver, brain and placenta.
Background: OPTN is also known as NRP, FIP2 or HYPL. This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

分子量

66 kDa

基因ID

10133

途径

M Phase

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