OPTN 抗体 (AA 241-577)
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北京 101111
Quick Overview for OPTN 抗体 (AA 241-577) (ABIN6719352)
抗原
See all OPTN 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 241-577
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原理
- Anti-Optineurin/OPTN Antibody (monoclonal, 3D8)
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Optineurin/OPTN Antibody (monoclonal, 3D8) (ABIN6719352). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Optineurin recombinant protein (Position: R241-I577). Human Optineurin shares 82% amino acid (aa) sequence identity with both mouse and rat Optineurin.
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亚型
- IgG2b
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anti-Optineurin (OPTN) antibody
KD Validated OPTN 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB4715 unconjugated Recombinant Antibody
anti-Optineurin (OPTN) (AA 341-440) antibodyOPTN 适用: 人, 小鼠 WB, ELISA, ICC, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Optineurin (OPTN) (AA 1-300) antibodyOPTN 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Optineurin (OPTN) (AA 1-577) antibodyOPTN 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Optineurin (OPTN) antibodyOPTN 适用: 人 WB, IP, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Optineurin (OPTN) (AA 1-577) antibodyOPTN 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Optineurin (OPTN) (AA 575-591) antibodyOPTN 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Optineurin (OPTN) (AA 1-577) antibodyOPTN 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Optineurin (OPTN) (AA 559-575) antibodyOPTN 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Optineurin (OPTN) (AA 72-121) antibodyOPTN 适用: 人, 小鼠, 犬, 豚鼠, Cow, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL
Flow Cytometry (Fixed), 1-3 μg/1x106 cells
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说明
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Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- OPTN (Optineurin (OPTN))
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别名
- OPTN
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背景
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Synonyms: Optineurin, E3-14.7K-interacting protein, FIP-2, Huntingtin yeast partner L, Huntingtin-interacting protein 7,HIP-7, Huntingtin-interacting protein L, NEMO-related protein, Optic neuropathy-inducing protein, Transcription factor IIIA-interacting protein, TFIIIA-IntP, OPTN, FIP2, GLC1E, HIP7, HYPL, NRP
Tissue Specificity: Present in aqueous humor of the eye. Highly expressed in trabecular meshwork. Expressed nonpigmented ciliary epithelium, retina, brain, adrenal cortex, fetus, lymphocyte, fibroblast, skeletal muscle, heart, liver, brain and placenta.
Background: OPTN is also known as NRP, FIP2 or HYPL. This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
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分子量
- 66 kDa
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基因ID
- 10133
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途径
- M Phase
抗原
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