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SYVN1 抗体 (AA 531-617)

Name: SYVN1 抗体 (AA 531-617)
SKU: ABIN671811
Availability: OutOfStock

This anti-SYVN1 antibody (ABIN671811) is a Rabbit Polyclonal antibody detecting SYVN1 in WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro). Suitable for Human, Mouse.

Formalin-fixed and paraffin embedded mouse kidney labeled with Rabbit Anti SYVN1/HRD1 Polyclonal Antibody, Unconjugated (ABIN671811) at 1:200 followed by conjugation to the secondary antibody and DAB staining (SYVN1 抗体 (AA 531-617))

IHC

Formalin-fixed and paraffin embedded mouse liver labeled with Rabbit Anti SYVN1/HRD1 Polyclonal Antibody, Unconjugated (ABIN671811) at 1:200 followed by conjugation to the secondary antibody and DAB staining (SYVN1 抗体 (AA 531-617))

IHC

2 images

(3 references)

产品编号 ABIN671811

发货至: 中国

Datasheet as PDF

Quick Overview for SYVN1 抗体 (AA 531-617) (ABIN671811)

抗原

See all SYVN1 抗体

SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))

适用

人, 小鼠

宿主

兔

克隆类型

多克隆

标记

This SYVN1 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

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AA 531-617

交叉反应

人, 小鼠

预测反应

Rat,Dog,Cow

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human SYVN1

亚型

IgG
anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 586-617), (C-Term) antibody
SYVN1 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB4822 unconjugated

anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 586-617) antibody
SYVN1 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (Internal Region) antibody
Verified SYVN1 适用: 人, 大鼠 WB, ELISA, FACS, IF 宿主: 山羊 Polyclonal unconjugated

anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (Internal Region) antibody
SYVN1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 338-487) antibody
SYVN1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (Internal Region) antibody
SYVN1 适用: 人, 小鼠, 大鼠, 马, 犬, Cow, 兔, Bat, 猴, Hamster, 非洲爪蟾, 斑马鱼 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 1-617) antibody
SYVN1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 238-318) antibody
SYVN1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4H4 unconjugated

anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 371-420) antibody
SYVN1 适用: 人, 小鼠, 大鼠, 马, 犬, 豚鼠, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated

anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 501-550) antibody
SYVN1 适用: 人, 小鼠, 大鼠, 马, 豚鼠, Bat WB 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Yang, He, Ma, Zhang, Zhu, Wan, Wang, Wang, Liu, Li: "Experimental study of the protective effects of SYVN1 against diabetic retinopathy." in: Scientific reports, Vol. 5, pp. 14036, (2016) (PubMed).

Zemoura, Schenkel, Acuña, Yévenes, Zeilhofer, Benke: "Endoplasmic reticulum-associated degradation controls cell surface expression of ?-aminobutyric acid, type B receptors." in: The Journal of biological chemistry, Vol. 288, Issue 48, pp. 34897-905, (2013) (PubMed).

Yan, Zheng, Chen, Liu, Li, Hu, Pei, Li: "Expression of endoplasmic reticulum stress-related factors in the retinas of diabetic rats." in: Experimental diabetes research, Vol. 2012, pp. 743780, (2011) (PubMed).
抗原

SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))

别名

SYVN1

背景

Synonyms: DER3, HRD1, E3 ubiquitin-protein ligase synoviolin, Synovial apoptosis inhibitor 1, SYVN1, KIAA181
Background: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.

基因ID

84447

UniProt

Q86TM6

途径

ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling