SYVN1 抗体 (AA 531-617)
Quick Overview for SYVN1 抗体 (AA 531-617) (ABIN671811)
抗原
See all SYVN1 抗体适用
宿主
克隆类型
标记
应用范围
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                                            抗原表位
- AA 531-617
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                                            交叉反应
- 人, 小鼠
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                                            预测反应
- Rat,Dog,Cow
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                                            纯化方法
- Purified by Protein A.
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                                            免疫原
- KLH conjugated synthetic peptide derived from human SYVN1
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                                            亚型
- IgG
 
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                                            应用备注
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                        WB 1:300-5000
 ELISA 1:500-1000
 FCM 1:20-100
 IHC-P 1:200-400
 IHC-F 1:100-500
 IF(IHC-P) 1:50-200
 IF(IHC-F) 1:50-200
 IF(ICC) 1:50-200
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                                            限制
- 仅限研究用
 
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                                            状态
- Liquid
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                                            浓度
- 1 μg/μL
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                                            缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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                                            储存液
- ProClin
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                                            注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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                                            储存条件
- 4 °C,-20 °C
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                                            储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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                                            有效期
- 12 months
 
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    - 
                                            : "Experimental study of the protective effects of SYVN1 against diabetic retinopathy."    in: Scientific reports, Vol. 5, pp. 14036, (2016)         (PubMed).        
 : "Endoplasmic reticulum-associated degradation controls cell surface expression of ?-aminobutyric acid, type B receptors." in: The Journal of biological chemistry, Vol. 288, Issue 48, pp. 34897-905, (2013) (PubMed).
 : "Expression of endoplasmic reticulum stress-related factors in the retinas of diabetic rats." in: Experimental diabetes research, Vol. 2012, pp. 743780, (2011) (PubMed).
 
 
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                                            : "Experimental study of the protective effects of SYVN1 against diabetic retinopathy."    in: Scientific reports, Vol. 5, pp. 14036, (2016)         (PubMed).        
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    - SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))
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                                            别名
- SYVN1
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                                            背景
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                        Synonyms: DER3, HRD1, E3 ubiquitin-protein ligase synoviolin, Synovial apoptosis inhibitor 1, SYVN1, KIAA181 Background: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. 
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                                            基因ID
- 84447
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                                            UniProt
- Q86TM6
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                                            途径
- ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling
 抗原
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