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KIT 抗体 (AA 901-976)

Name: KIT 抗体 (AA 901-976)
SKU: ABIN671721
Availability: OutOfStock

This anti-KIT antibody is a 兔多克隆 antibody detecting KIT in WB, FACS, ELISA, IF (cc), IF (p), IHC (p), ICC 和 IHC (fro). Suitable for 人, 小鼠和大鼠. This Primary Antibody has been cited in 4+ publications.

Formalin-fixed and paraffin embedded rat kidney tissue labeled Anti-CD117/c-kit/SCFR Polyclonal Antibody, Unconjugated (ABIN671721) at 1:200, followed by conjugation to the secondary antibody and DAB staining (KIT 抗体 (AA 901-976))

IHC

Formalin-fixed and paraffin embedded rat kidney tissue labeled Anti-CD117/c-kit/SCFR Polyclonal Antibody, Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining (KIT 抗体 (AA 901-976))

IHC (p)

2 images

(4 references)

产品编号 ABIN671721

发货至: 中国

Datasheet as PDF

Quick Overview for KIT 抗体 (AA 901-976) (ABIN671721)

抗原

See all KIT 抗体

KIT (Mast/stem Cell Growth Factor Receptor (KIT))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This KIT antibody is un-conjugated

应用范围

Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Discover our top product KIT Primary Antibody

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AA 901-976

交叉反应

人, 小鼠, 大鼠

预测反应

Dog,Cow,Rabbit

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human CD117/c-kit

亚型

IgG
anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 350-440) antibody
KIT 适用: 人, 小鼠, 大鼠 FACS, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 321-520) antibody
KIT 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 343-527) antibody
KIT 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Mast/stem Cell Growth Factor Receptor (KIT) (Internal Region) antibody
Verified KIT 适用: 人 WB, FACS, ELISA, IHC, IF 宿主: 山羊 Polyclonal unconjugated

anti-Mast/stem Cell Growth Factor Receptor (KIT) (pTyr721) antibody
KIT 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Mast/stem Cell Growth Factor Receptor (KIT) (pTyr703) antibody
KIT 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 546-976) antibody
KIT 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2E3 unconjugated

anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 25-295) antibody
KIT 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Mast/stem Cell Growth Factor Receptor (KIT) antibody (FITC)
KIT 适用: 人, Cow, Non-Human Primate FACS 宿主: 小鼠 Monoclonal 104D2 FITC

anti-Mast/stem Cell Growth Factor Receptor (KIT) antibody
KIT 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 1C5 unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Yin, Liang, Wang, Yan, Yin, Wu, Su: "Naringenin induces laxative effects by upregulating the expression levels of c-Kit and SCF, as well as those of aquaporin 3 in mice with loperamide-induced constipation." in: International journal of molecular medicine, Vol. 41, Issue 2, pp. 649-658, (2018) (PubMed).

Lin, Tang, Cai, Wang, Li, Sui, Guo: "NPs/NPRs Signaling Pathways May Be Involved in Depression-Induced Loss of Gastric ICC by Decreasing the Production of mSCF." in: PLoS ONE, Vol. 11, Issue 2, pp. e0149031, (2016) (PubMed).

Lu, Luo, Sun, Qin, Li: "Electroacupuncture improves behavioral recovery and increases SCF/c-kit expression in a rat model of focal cerebral ischemia/reperfusion." in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, Vol. 34, Issue 4, pp. 487-95, (2013) (PubMed).

Zhang, Huang, Wu, Yang, Song, Chen, Fan, Wang: "Cardiac stem cells differentiate into sinus node-like cells." in: The Tohoku journal of experimental medicine, Vol. 222, Issue 2, pp. 113-20, (2010) (PubMed).
抗原

KIT (Mast/stem Cell Growth Factor Receptor (KIT))

别名

c-Kit

背景

Synonyms: PBT, SCFR, C-Kit, CD117, Mast/stem cell growth factor receptor Kit, Piebald trait protein, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit, p145 c-kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, KIT
Background: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.

基因ID

3815

UniProt

P10721

途径

RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity