CDK7 抗体 (AA 1-80)
Quick Overview for CDK7 抗体 (AA 1-80) (ABIN670251)
抗原
See all CDK7 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1-80
-
交叉反应
- 人, 小鼠, 大鼠
-
预测反应
- Cow
-
纯化方法
- Purified by Protein A.
-
免疫原
- KLH conjugated synthetic peptide derived from human CDK7
-
亚型
- IgG
-
-
anti-Cyclin-Dependent Kinase 7 (CDK7) (AA 1-346) antibody
CDK7 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 7 (CDK7) (AA 1-346) antibodyCDK7 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 7 (CDK7) (AA 1-346) antibodyCDK7 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 7 (CDK7) (C-Term) antibodyCDK7 适用: 人, 小鼠, 大鼠, Cow, 马, Pig, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 7 (CDK7) (AA 211-346) antibodyCDK7 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 7 (CDK7) (pThr170) antibodyCDK7 适用: 人, 小鼠 WB, IHC (p), DB 宿主: 兔 Polyclonal RB07518 unconjugated
anti-Cyclin-Dependent Kinase 7 (CDK7) (C-Term) antibodyCDK7 适用: 人, 小鼠, 大鼠, Cow, 马, Pig, 犬, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 7 (CDK7) (AA 212-341) antibodyCDK7 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 7 (CDK7) (C-Term) antibodyCDK7 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 7 (CDK7) (AA 1-130) antibodyCDK7 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
-
-
应用备注
-
WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 μg/μL
-
缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
-
有效期
- 12 months
-
-
- CDK7 (Cyclin-Dependent Kinase 7 (CDK7))
-
别名
- CDK7
-
背景
-
Synonyms: CAK1, HCAK, MO15, STK1, CDKN7, p39MO15, Cyclin-dependent kinase 7, 39 kDa protein kinase, p39 Mo15, CDK-activating kinase 1, Cell division protein kinase 7, Serine/threonine-protein kinase 1, TFIIH basal transcription factor complex kinase subunit, CDK7, CAK
Background: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53, this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.
-
基因ID
- 1022
-
UniProt
- P50613
-
途径
- Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, M Phase
抗原
-
