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KIT Ligand 抗体 (PE-Cy5)

This anti-KIT Ligand antibody is a 兔 多克隆 antibody detecting KIT Ligand in WB 和 FACS. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN669948
发货至: 中国

Quick Overview for KIT Ligand 抗体 (PE-Cy5) (ABIN669948)

抗原

See all KIT Ligand (KITLG) 抗体
KIT Ligand (KITLG)

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This KIT Ligand antibody is conjugated to PE-Cy5

应用范围

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Western Blotting (WB), Flow Cytometry (FACS)
  • 交叉反应

    人, 小鼠, 大鼠

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human SCF

    亚型

    IgG
  • 应用备注

    WB(1:100-500)
    FCM(1:100-500)
    IHC-P(1:100-500)
    IHC-F(1:100-500)
    IF(IHC-P)(1:100-500)
    IF(IHC-F)(1:100-500)

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    KIT Ligand (KITLG)

    别名

    SCF

    背景

    Synonyms: SF, MGF, SCF, FPH2, KL-1, Kitl, SHEP7, Kit ligand, Mast cell growth factor, Stem cell factor, c-Kit ligand, KITLG

    Background: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

    分子量

    31kDa

    基因ID

    4254

    UniProt

    P21583

    途径

    RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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