WNK4 抗体 (AA 351-450)
Quick Overview for WNK4 抗体 (AA 351-450) (ABIN668526)
抗原
See all WNK4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 351-450
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交叉反应
- 小鼠
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预测反应
- Human,Rat
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human WNK4
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亚型
- IgG
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anti-WNK Lysine Deficient Protein Kinase 4 (WNK4) (AA 828-1106) antibody
WNK4 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 4 (WNK4) (AA 1144-1243) antibodyWNK4 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 1E6 unconjugated
anti-WNK Lysine Deficient Protein Kinase 4 (WNK4) antibodyWNK4 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- WNK4 (WNK Lysine Deficient Protein Kinase 4 (WNK4))
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别名
- WNK4
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背景
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Synonyms: PHA 2B, PHA2B, PRKWNK 4, PRKWNK4, Protein kinase lysine deficient 4, Protein kinase with no lysine 4, Serine/threonine protein kinase WNK4, WNK lysine deficient protein kinase 4, WNK4_HUMAN.
Background: Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+)channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+)secretion to maintain integrated homeostasis.
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基因ID
- 65266
抗原
-
