FMR1 抗体 (pSer499)
Quick Overview for FMR1 抗体 (pSer499) (ABIN6658159)
抗原
See all FMR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer499
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Supplier Product No.
- 600-401-x07
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Supplier
- Rockland
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原理
- FMRP Phospho S499 Antibody
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交叉反应 （详细）
- Anti-Anti-FMRP pS499 Antibody is directed against FMRP protein phosphorylated at S499.
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纯化方法
- The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities.
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过滤
- Sterile filtered
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免疫原
- Anti-Phospho-Ser499 FMRP Antibody was produced in rabbits by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser499 of rat FRMP conjugated to KLH.
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亚型
- IgG
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anti-Fragile X Mental Retardation 1 (FMR1) (AA 36-279) antibody
FMR1 适用: 人, 小鼠, 大鼠, 犬, 猴 WB, IHC, IF, IHC (p), FACS 宿主: 小鼠 Monoclonal 1C6 unconjugated
anti-Fragile X Mental Retardation 1 (FMR1) (AA 26-279) antibodyFMR1 适用: 人, 小鼠, 大鼠, 犬, 猴 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2C3 unconjugated
anti-Fragile X Mental Retardation 1 (FMR1) antibodyFMR1 适用: 人 WB, IHC, IF, IHC (p), FACS 宿主: 小鼠 Monoclonal 3B4 unconjugated
anti-Fragile X Mental Retardation 1 (FMR1) (AA 121-220) antibodyFMR1 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 2D4 unconjugated
anti-Fragile X Mental Retardation 1 (FMR1) (AA 1-290) antibodyFMR1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fragile X Mental Retardation 1 (FMR1) (AA 500-600) antibodyFMR1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Fragile X Mental Retardation 1 (FMR1) (AA 116-130) antibodyVerified FMR1 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Fragile X Mental Retardation 1 (FMR1) (AA 121-220) antibodyFMR1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3E11 unconjugated
anti-Fragile X Mental Retardation 1 (FMR1) antibodyFMR1 适用: 人 IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 4G9 unconjugated
anti-Fragile X Mental Retardation 1 (FMR1) (AA 20-48), (N-Term) antibodyFMR1 适用: 人, 小鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB20964 unconjugated
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应用备注
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ELISA_Dilution: 1:10,000
Immunohistochemistry_Dilution: 1:250-1:1000
Western_Blot_Dilution: 1:1000
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说明
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Anti-Phospho-Ser499 FMRP Antibody is tested for Western Blot and immunohistochemistry and is specific for the ~71 kDa FMRP protein phosphorylated at Ser499. Immunolabeling of the FMRP protein is completely eliminated by lambda-phosphatase. Specific conditions for reactivity should be optimized by the end user.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol
Preservative: None -
储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- Store vial at -20° C prior to opening in undiluted aliquots. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
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有效期
- 12 months
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- FMR1 (Fragile X Mental Retardation 1 (FMR1))
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别名
- FMRP
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背景
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Synonyms: Fragile X mental retardation protein 1 homolog, FMR-1
Background: Fragile X Mental Retardation Protein (FMRP) is an RNA-binding protein that plays an essential role in cognitive brain function. Mutations in the FMR1 gene, which codes for FMRP, can result in fragile X syndrome, autism, as well as other cognitive deficits. Phosphorylation of the highly conserved Ser499 has been shown to trigger hierarchical phosphorylation of nearby serines and may play a role in suppressing target mRNA translation. FMRP pS499 Antibody is ideal for researchers interested in neuroscience research.
Gene Name: FMR1
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基因ID
- 24948
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NCBI登录号
- NP_434691
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UniProt
- Q80WE1
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途径
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
抗原
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