NMDAR2A 抗体 (C-Term)
Quick Overview for NMDAR2A 抗体 (C-Term) (ABIN6658061)
抗原
See all NMDAR2A (GRIN2A) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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Supplier Product No.
- 600-401-c86
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Supplier
- Rockland
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原理
- NMDA NR2A Subunit Antibody
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交叉反应 (详细)
- Anti-NMDA NR2A Subunit antibody is directed against NMDA NR2A protein.
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纯化方法
- The antibody was affinity purified from monospecific antiserum by immunoaffinity purification.
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免疫原
- Anti-NMDA NR2A subunit Antibody was produced by repeated immunizations with a fusion protein from the C-terminal region of the NR2A subunit.
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亚型
- IgG
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应用备注
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Immunoprecipitation_Dilution: 3 μL per 200 μg lysate
Immunohistochemistry_Dilution: 1:1000-1:2000
Western_Blot_Dilution: 1:1000
Other: User Optimized
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说明
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Anti-NMDA NR2A Subunit (Rabbit) Antibody is tested for use in Western Blotting, Immunoprecipitation and IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 180 kDa in size corresponding to the NR2A subunit of the NMDA receptor. This antibody is lyophilized from 5 mM ammonium bicarbonate.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
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Reconstitution_Buffer: Neutral PBS
Reconstitution_Volume: 50μL
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at 4° C prior to restoration. For extended storage aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. Dilute only prior to immediate use.
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有效期
- 12 months
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- NMDAR2A (GRIN2A) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A))
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别名
- NMDA NR2A Subunit
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背景
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Synonyms: Glutamate [NMDA] receptor subunit epsilon-1, N-methyl D-aspartate receptor subtype 2A, NMDAR2A, NR2A, Grin2a
Background: NMDA NR2A Subunit antibody detects NMDA NR2A protein. The ion channels activated by glutamate are typically divided into two classes. Glutamate receptors that are activated by kainate and α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The NMDAR is also potentiated by protein phosphorylation. The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. Anti-NMDA NR2A Subunit Antibody is ideal for investigators involved in Neuroscience and Signal Transduction research.
Gene Name: GRIN2A
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基因ID
- 24409
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NCBI登录号
- NP_036705
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UniProt
- Q00959
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途径
- Synaptic Membrane, Regulation of long-term Neuronal Synaptic Plasticity
抗原
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