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RAGE 抗体 (Internal Region)

This anti-RAGE antibody is a 兔 多克隆 antibody detecting RAGE in WB 和 IHC. Suitable for 人. This Primary Antibody has been cited in 1 publication.
Rockland
产品编号 ABIN6657517
Supplier Product No.: 600-401-p67
发货至: 中国

Quick Overview for RAGE 抗体 (Internal Region) (ABIN6657517)

抗原

See all RAGE (AGER) 抗体
RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

适用

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宿主

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克隆类型

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多克隆

标记

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This RAGE antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC)
  • 抗原表位

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    Internal Region

    Supplier Product No.

    600-401-p67

    Supplier

    Rockland

    原理

    AGER/RAGE Antibody

    交叉反应 (详细)

    Anti-RAGE antibody is directed against human RAGE protein.

    纯化方法

    The product was affinity purified from monospecific antiserum by immunoaffinity purification.

    免疫原

    AGER/RAGE affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of human RAGE.

    亚型

    IgG
  • 应用备注

    Immunohistochemistry_Dilution: 1:100-1:500

    Western_Blot_Dilution: 0.5 μg/mL

    说明

    Suggested Applications: IF
    Anti-RAGE is tested for Immunohistochemistry-P, -F, and Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately ~42.8 kDa corresponding to the appropriate cell lysate or extract.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Reconstitution_Buffer: Restore with deionized water (or equivalent)

    Reconstitution_Volume: 250 μL

    缓冲液

    Buffer: 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide

    Stabilizer: 5 mg BSA

    Preservative: 0.05 mg Thimerosal

    储存液

    Thimerosal (Merthiolate)

    注意事项

    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store vial at 4° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

    有效期

    12 months
  • Bochi, Ferreira, Del Bianco, Pinto, Rodrigues, Trevisani, Furukawa, Bispo, da Silva, Velosa, Nakandakare, Machado, Teodoro, Passarelli, Catanozi: "Aerobic Exercise Training Reduces Atherogenesis Induced by Low-Sodium Diet in LDL Receptor Knockout Mice." in: Antioxidants (Basel, Switzerland), Vol. 11, Issue 10, (2022) (PubMed).

  • 抗原

    RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

    别名

    AGER/RAGE

    背景

    Synonyms: Receptor for advanced glycosylation end products,

    Background: The receptor for advanced glycation end products (RAGE) is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules. It interacts with distinct molecules implicated in homeostasis, development and inflammation, and certain diseases such as diabetes and Alzheimer's disease. RAGE is also a central cell surface receptor for amphoterin and EN-RAGE. RAGE is associated with sustained NF-kappaB activation in the diabetic microenvironment and has a central role in sensory neuronal dysfunction. Moreover, RAGE propagates cellular dysfunction in several inflammatory disorders and diabetes, and it also functions as an endothelial adhesion receptor promoting leukocyte recruitment. This antibody is suitable for researchers interested in neuroscience research.

    Gene Name: AGER

    基因ID

    177

    NCBI登录号

    NP_001127

    UniProt

    Q15109

    途径

    Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins
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