RAGE 抗体 (Internal Region)
Quick Overview for RAGE 抗体 (Internal Region) (ABIN6657517)
抗原
See all RAGE (AGER) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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Supplier Product No.
- 600-401-p67
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Supplier
- Rockland
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原理
- AGER/RAGE Antibody
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交叉反应 (详细)
- Anti-RAGE antibody is directed against human RAGE protein.
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纯化方法
- The product was affinity purified from monospecific antiserum by immunoaffinity purification.
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免疫原
- AGER/RAGE affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of human RAGE.
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亚型
- IgG
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应用备注
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Immunohistochemistry_Dilution: 1:100-1:500
Western_Blot_Dilution: 0.5 μg/mL
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说明
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Suggested Applications: IF
Anti-RAGE is tested for Immunohistochemistry-P, -F, and Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately ~42.8 kDa corresponding to the appropriate cell lysate or extract. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
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Reconstitution_Buffer: Restore with deionized water (or equivalent)
Reconstitution_Volume: 250 μL
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缓冲液
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Buffer: 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide
Stabilizer: 5 mg BSA
Preservative: 0.05 mg Thimerosal -
储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at 4° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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: "Aerobic Exercise Training Reduces Atherogenesis Induced by Low-Sodium Diet in LDL Receptor Knockout Mice." in: Antioxidants (Basel, Switzerland), Vol. 11, Issue 10, (2022) (PubMed).
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: "Aerobic Exercise Training Reduces Atherogenesis Induced by Low-Sodium Diet in LDL Receptor Knockout Mice." in: Antioxidants (Basel, Switzerland), Vol. 11, Issue 10, (2022) (PubMed).
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- RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))
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别名
- AGER/RAGE
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背景
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Synonyms: Receptor for advanced glycosylation end products,
Background: The receptor for advanced glycation end products (RAGE) is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules. It interacts with distinct molecules implicated in homeostasis, development and inflammation, and certain diseases such as diabetes and Alzheimer's disease. RAGE is also a central cell surface receptor for amphoterin and EN-RAGE. RAGE is associated with sustained NF-kappaB activation in the diabetic microenvironment and has a central role in sensory neuronal dysfunction. Moreover, RAGE propagates cellular dysfunction in several inflammatory disorders and diabetes, and it also functions as an endothelial adhesion receptor promoting leukocyte recruitment. This antibody is suitable for researchers interested in neuroscience research.
Gene Name: AGER
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基因ID
- 177
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NCBI登录号
- NP_001127
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UniProt
- Q15109
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途径
- Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins
抗原
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