GPBAR1 抗体 (C-Term)
Quick Overview for GPBAR1 抗体 (C-Term) (ABIN6657009)
抗原
See all GPBAR1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- C-Term
-
Supplier Product No.
- 100-401-h59
-
Supplier
- Rockland
-
原理
- BG37 Antibody
-
交叉反应 （详细）
- A BLAST analysis was used to suggest cross-reactivity with BG37 from human and mouse based on 100 % homology with the immunizing sequence.
-
纯化方法
- Anti-BG37 Antibody is sera.
-
免疫原
- BG37 Antibody was produced from whole rabbit serum which was prepared by repeated immunizations with the amino acid portion of human BG37 near the C-terminus of the chain .
-
亚型
- IgG
-
-
anti-G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) (C-Term) antibody
GPBAR1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) (Cytoplasmic Domain) antibodyGPBAR1 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optional[Neutralization_Dilution]: 1:1000-1:5000
-
说明
-
Anti-BG37 Antibody has been tested in WB. Expect a band approximately 37kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Optional[Buffer]: 50 % (v/v) Glycerol ,0.05 % (w/v) Sodium Azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
-
有效期
- 12 months
-
-
- GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))
-
别名
- BG37
-
背景
-
Synonyms: TGR5, G-protein coupled bile acid receptor 1, G-protein coupled receptor GPCR19, hGPCR19, Membrane-type receptor for bile acids, M-BAR, hBG37, BG37
Background: Anti-BG37 TGR5 Antibody detects human BG37tgr5. BG37 is a 330 amino acid novel enzyme with seven transmembrane domains. It belongs to the G protein-coupled receptor (GPCR) superfamily and functions as a cell surface receptor for bile acids. Cells expressing BG37 when treated with bile acids induce the production of intracellular cAMP, activate the MAP kinase signaling pathway, leads to the internalization of the receptor and regulates proglucagon gene expression in enteroendocrine cells. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids that can be targeted to improve metabolic control. It is known to be ubiquitously expressed in most of the tissues. Anti-BG37 TGR5 Antibody is ideal for investigators involved in kinase, phosphatase, and NFkappaB research.
Gene Name: GPBAR1
-
基因ID
- 151306
-
NCBI登录号
- NP_001070659
-
UniProt
- Q8TDU6
-
途径
- WNT signaling, Hormone Transport, Sensory Perception of Sound
抗原
-
