FKBP4 抗体
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北京 101111
Quick Overview for FKBP4 抗体 (ABIN6656074)
抗原
See all FKBP4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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Supplier Product No.
- 200-301-f29
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Supplier
- Rockland
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原理
- FKBP52 Antibody
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交叉反应 （详细）
- A BLAST analysis was used to suggest cross-reactivity with FKBP52 from Canine, Hamster, Human, Mouse, and Rat based on 100 % homology with the immunizing sequence.
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纯化方法
- Anti-FKBP52 Antibody was purified by Protein G chromatography.
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过滤
- Sterile filtered
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免疫原
- FKBP51 Antibody was produced in mice by repeated immunizations with a synthetic peptide corresponding to the residues of human FKBP51.
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亚型
- IgG
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anti-FK506 Binding Protein 4, 59kDa (FKBP4) (AA 301-410) antibody
FKBP4 适用: 人 WB, IP, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 5C11 unconjugated
anti-FK506 Binding Protein 4, 59kDa (FKBP4) (AA 2-459) antibodyFKBP4 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-FK506 Binding Protein 4, 59kDa (FKBP4) (AA 220-459) antibodyFKBP4 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-FK506 Binding Protein 4, 59kDa (FKBP4) (AA 1-459) antibodyFKBP4 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-FK506 Binding Protein 4, 59kDa (FKBP4) (AA 1-459) antibodyFKBP4 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-FK506 Binding Protein 4, 59kDa (FKBP4) antibodyFKBP4 适用: 人 WB, IHC, IP, IF, ICC 宿主: 小鼠 Monoclonal Hi52C unconjugated
anti-FK506 Binding Protein 4, 59kDa (FKBP4) antibodyFKBP4 适用: 人, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-FK506 Binding Protein 4, 59kDa (FKBP4) antibody (HRP)FKBP4 适用: 人 WB, IHC, IP, IF, ICC 宿主: 小鼠 Monoclonal Hi52C HRP
anti-FK506 Binding Protein 4, 59kDa (FKBP4) antibody (FITC)FKBP4 适用: 人 WB, IHC, IP, IF, ICC 宿主: 小鼠 Monoclonal Hi52C FITC
anti-FK506 Binding Protein 4, 59kDa (FKBP4) antibody (Biotin)FKBP4 适用: 人 WB, IHC, IP, IF, ICC 宿主: 小鼠 Monoclonal Hi52C Biotin
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应用备注
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Immunoprecipitation_Dilution: 5 μg/20uL
Immunohistochemistry_Dilution: 1:250
Western_Blot_Dilution: 1:2000
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说明
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Anti-FKBP52 Antibody is tested for WB, IP, IF, and IHC. Expect a band approximately ~52kDa protein representing FKBP52 in cell lysates. Heavy chain migrates close to FKBP52 on SDS PAGE. Specific conditions for reactivity should be optimized by the end user.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: 50 % (v/v) Glycerol
Preservative: 0.09 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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- FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))
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别名
- FKBP52
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背景
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Synonyms: FK506 binding protein 4, FKBP4, FKBP59, HBI, Hsp56, p52, p59, PPIase, Rotamase, T cell FK506 binding protein, FKBP52
Background: Hsp90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones. One class of Hsp90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an Hsp90 binding site. Among the TPR cochaperones of Hsp90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin A-binding families of immunophilins. FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex. The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the Hsp90. Although FKBP52 and FKBP51 share ~75 % sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different Hsp90-binding characteristics . FK506 binding protein 51 kDa (FKBP51 or otherwise referred to as FKBP54) has been identified as a progestininducible gene. This protein is predominantly expressed in murine T cells but in humans, it is abundantly expressed in numerous tissues at levels many times higher than FKBP12. The FKBP51 gene is known to be induced by glucocorticoids.
Gene Name: FKBP4
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基因ID
- 2288
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NCBI登录号
- NP_002005
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UniProt
- Q02790
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway
抗原
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