TBK1 抗体
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北京 101111
Quick Overview for TBK1 抗体 (ABIN6655825)
抗原
See all TBK1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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Supplier Product No.
- 200-301-i22
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Supplier
- Rockland
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原理
- TBK1 Antibody
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交叉反应 （详细）
- A BLAST analysis was used to suggest cross-reactivity with Anti-TBK1 from Human, Mouse, cow, dog and rat based on 100 % homology with the immunizing sequence.
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纯化方法
- Anti-TBK1 Antibody was purified by Protein G chromatography.
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免疫原
- TBK1 Antibody was produced in mice prepared by repeated immunizations with a synthetic peptide corresponding to internal amino acids of the human protein TBK1.
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亚型
- IgG1 kappa
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anti-TANK-Binding Kinase 1 (TBK1) (AA 440-729) antibody
TBK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-TANK-Binding Kinase 1 (TBK1) (pSer172) antibodyTBK1 适用: 小鼠, 大鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-TANK-Binding Kinase 1 (TBK1) (AA 9-310) antibodyTBK1 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-TANK-Binding Kinase 1 (TBK1) antibodyKD Validated TBK1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB4650 unconjugated Recombinant Antibody
anti-TANK-Binding Kinase 1 (TBK1) (AA 150-181) antibodyTBK1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB16573 unconjugated
anti-TANK-Binding Kinase 1 (TBK1) (AA 364-585) antibodyTBK1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-TANK-Binding Kinase 1 (TBK1) (pSer172) antibodyKD Validated TBK1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB2150 unconjugated Recombinant Antibody
anti-TANK-Binding Kinase 1 (TBK1) (AA 644-661) antibodyTBK1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-TANK-Binding Kinase 1 (TBK1) (AA 514-527) antibodyVerified TBK1 适用: 人 WB, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-TANK-Binding Kinase 1 (TBK1) (Internal Region) antibodyTBK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optional[Neutralization_Dilution]: 1-2 μg/mL
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说明
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Anti-TBK1 Antibody is tested for use in WB, ICC/IF, IHC, IHC-P, and IP. Expect a band approximately 80kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: 0.05 % BSA
Preservative: 0.05 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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- TBK1 (TANK-Binding Kinase 1 (TBK1))
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别名
- TBK1
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背景
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Synonyms: NAK, Nuclear receptor subfamily 4 group A member 1, Early response protein NAK1, Nuclear hormone receptor NUR/77, Nur77, Orphan nuclear receptor HMR, Orphan nuclear receptor TR3, ST-59, Testicular receptor 3, Serine/threonine-protein kinase TBK1, NF-kappa-B-activating kinase, T2K, TANK-binding kinase 1
Background: Anti-TBK1 NAK Antibody detects human TBK1 NAK. NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing it's translocation to the nucleus. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g. IKK1/a and IKK2/b are phosphorylated by NF-kB-inducing kinase (NIK) and MAP kinase kinase kinase-1 (MEKK1), respectively. Recently, a new IKK family member, TBK1 [(TANK-binding kinase), also known as NAK and T2K] has been identified. TANK (TRAF-associated NF-kB activator) interacts with TBK1 and activates NF-kB in a kinase dependent manner. Anti-TBK1 NAK Antibody is ideal for investigators involved in NFkappaB and apoptosis research.
Gene Name: TBK1
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基因ID
- 29110
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NCBI登录号
- NP_037386
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UniProt
- Q9UHD2
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途径
- TLR signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interactome
抗原
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