APP 抗体
(7 references)
Quick Overview for APP 抗体 (ABIN6655723)
抗原
See all APP 抗体适用
宿主
克隆类型
标记
应用范围
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Supplier Product No.
- 200-401-e88
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Supplier
- Rockland
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原理
- Amyloid Oligomers (A11) Antibody
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交叉反应 （详细）
- A BLAST analysis was used to suggest cross-reactivity with Amyloid Oligomers (A11) from Eukaryotes, Human, Mouse, and Rat based on 100 % homology with the immunizing sequence.
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纯化方法
- Anti-Amyloid Oligomers (A11) Antibody was purified by Protein A chromatography.
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过滤
- Sterile filtered
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免疫原
- Amyloid Oligomers (A11) Antibody was produced from whole rabbit serum prepared by repeated immunizations with synthetic molecular mimic of soluble oligomers.
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亚型
- IgG
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anti-Amyloid beta (A4) Precursor Protein (APP) (C-Term) antibody
APP 适用: 人 WB, IF, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein (APP) antibodyAPP 适用: 人, 小鼠 WB, ELISA, IHC, IF, FM 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein (APP) (AA 666-670) antibodyAPP 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein (APP) (AA 18-270) antibodyAPP 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein (APP) (C-Term) antibodyAPP 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein (APP) antibodyKO Validated APP 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein (APP) (AA 381-480) antibodyAPP 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein (APP) (pThr668) antibodyAPP 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein (APP) antibodyAPP 适用: 人 WB, ELISA, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein (APP) (C-Term) antibodyAPP 适用: 人, 小鼠, 大鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunoprecipitation_Dilution: 1:200
ELISA_Dilution: 0.1-10 μg/mL
Immunohistochemistry_Dilution: 1:1000-10,000
IF_Microscopy_Dilution: User Optimized
Western_Blot_Dilution: 1:200
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说明
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Suggested Applications: Other
Anti-Amyloid Oligomers (A11) Antibody is tested for use in IP, IF microscopy, IHC, and WB. Specific conditions for reactivity should be optimized by the end user. -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: 50 % (v/v) Glycerol
Preservative: 0.09 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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: "Amyloid aggregates induced by the p53-R280T mutation lead to loss of p53 function in nasopharyngeal carcinoma." in: Cell death & disease, Vol. 15, Issue 1, pp. 35, (2024) (PubMed).
: "Aβ∗56 is a stable oligomer that impairs memory function in mice." in: iScience, Vol. 27, Issue 3, pp. 109239, (2024) (PubMed).
: "The divergent effects of astrocyte ceruloplasmin on learning and memory function in young and old mice." in: Cell death & disease, Vol. 13, Issue 11, pp. 1006, (2022) (PubMed).
: "Iron potentiates microglial interleukin-1β secretion induced by amyloid-β." in: Journal of neurochemistry, Vol. 154, Issue 2, pp. 177-189, (2020) (PubMed).
: "Cerebrovascular miRNAs correlate with the clearance of Aβ through perivascular route in younger 3xTg-AD mice." in: Brain pathology (Zurich, Switzerland), Vol. 30, Issue 1, pp. 92-105, (2020) (PubMed).
: "Multifunctionalized Reduced Graphene Oxide Biosensors for Simultaneous Monitoring of Structural Changes in Amyloid-β 40." in: Sensors (Basel, Switzerland), Vol. 18, Issue 6, (2018) (PubMed).
: "Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease." in: Neurobiology of disease, Vol. 93, pp. 215-25, (2018) (PubMed).
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: "Amyloid aggregates induced by the p53-R280T mutation lead to loss of p53 function in nasopharyngeal carcinoma." in: Cell death & disease, Vol. 15, Issue 1, pp. 35, (2024) (PubMed).
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- APP (Amyloid beta (A4) Precursor Protein (APP))
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别名
- APP
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背景
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Synonyms: Rabbit Anti-Amyloid Oligomer αβ Antibody, Rabbit Anti-Amyloid Oligomer alpha beta Antibody, Rabbit Anti-Amyloid Oligomers A11 Antibody, Amyloid beta A4 protein, Amyloid Oligomer AlphaBeta Antibody, APP Antibody, ABPP, APPI, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II, A4, AD1
Background: Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres. These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer's symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington's disease. Anti-Amyloid Oligomers A11 Antibody is useful for researchers interested in Neuroscience research.
Gene Name: APP
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基因ID
- 8666
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NCBI登录号
- NM_000484
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UniProt
- P05067
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途径
- Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour
抗原
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