Cyclin L2 抗体 (AA 309-384)
(3 references)
Quick Overview for Cyclin L2 抗体 (AA 309-384) (ABIN6655712)
抗原
See all Cyclin L2 (CCNL2) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 309-384
-
Supplier Product No.
- 600-401-878
-
Supplier
- Rockland
-
原理
- Cyclin L2 Antibody
-
交叉反应 （详细）
- This antibody is specific for human Cyclin L2a and shows negligible reactivity to Cyclin L2b or Cyclin L1 isoforms.
-
纯化方法
- This product is an affinity purified antibody produced by immunoaffinity chromatography using polypeptide coupled to agarose beads followed by solid phase adsorption(s) to remove any unwanted reactivities.
-
过滤
- Sterile filtered
-
免疫原
- This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic polypeptide corresponding to amino acids 309-384 of Human Cyclin L2a protein.
-
亚型
- IgG
-
-
anti-Cyclin L2 (CCNL2) antibody
CCNL2 适用: 人 IHC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin L2 (CCNL2) (AA 338-366) antibodyCCNL2 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cyclin L2 (CCNL2) (C-Term) antibodyCCNL2 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cyclin L2 (CCNL2) (AA 101-150) antibodyCCNL2 适用: 人, 大鼠, 小鼠, 犬, Cow, 豚鼠, 马, 兔, 小鸡, 非洲爪蟾, Bat, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Cyclin L2 (CCNL2) (AA 60-150) antibodyCCNL2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cyclin L2 (CCNL2) (N-Term) antibodyCCNL2 适用: 人, 大鼠, 小鼠, 犬, 小鸡, 非洲爪蟾, Drosophila melanogaster WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Immunoprecipitation_Dilution: 1:100
ELISA_Dilution: 1:2,000 - 1:10,000
Western_Blot_Dilution: 1:500 - 1:3,000
Other: User Optimized
-
说明
-
This affinity purified antibody has been tested for use in ELISA and western blot. Specific conditions for reactivity should be optimized by the end user. Expect a band ~ 58 kDa in size corresponding to Cyclin L2a by western blotting in the appropriate cell lysate or extract. Although not tested, this antibody is likely functional in immunohistochemistry, immunofluorescence, and immunoprecipitation.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
-
Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide -
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
-
有效期
- 12 months
-
-
-
: "CDK11 Loss Induces Cell Cycle Dysfunction and Death of BRAF and NRAS Melanoma Cells." in: Pharmaceuticals (Basel, Switzerland), Vol. 12, Issue 2, (2019) (PubMed).
: "Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy." in: Breast cancer research : BCR, Vol. 17, pp. 19, (2015) (PubMed).
: "Role of CDK/cyclin complexes in transcription and RNA splicing." in: Cellular signalling, Vol. 17, Issue 9, pp. 1033-51, (2005) (PubMed).
-
: "CDK11 Loss Induces Cell Cycle Dysfunction and Death of BRAF and NRAS Melanoma Cells." in: Pharmaceuticals (Basel, Switzerland), Vol. 12, Issue 2, (2019) (PubMed).
-
- Cyclin L2 (CCNL2)
-
别名
- Cyclin L2
-
背景
-
Synonyms: rabbit anti-Cyclin-L2 antibody, Cyclin L2, CCNL2, SB138, Paneth cell-enhanced expression protein, Cyclin Ania-6b, Paneth cell-enhanced expression protein, PCEE, Ania6b
Background: Cyclin L (also referred to as CCNL) is encoded by two highly related genes Cyclin L1 and Cyclin L2 (CCNL1 and CCNL2, respectively). Cyclin L2 can be alternatively spliced to produce two isoforms (known as 1 and 2 or alpha and beta). The Cyclin L2 gene is located approximately 100-200 kb from the PITSLRE/CDK11 protein kinase locus in human (1p36) and in a syngenetic location on mouse chromosome 4q. Cyclin L2 is ubiquitous, expressed at much higher levels than Cyclin L1, and thus is likely the major partner for the CDK11p110 protein kinase.
Gene Name: CCNL2, SB138
-
基因ID
- 81669, 14585859
-
UniProt
- Q96S94
抗原
-
