SH3GLB1 抗体 (C-Term)
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北京 101111
Quick Overview for SH3GLB1 抗体 (C-Term) (ABIN6655627)
抗原
See all SH3GLB1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- C-Term
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Supplier Product No.
- 200-301-h61
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Supplier
- Rockland
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原理
- BIF1 Antibody
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交叉反应 （详细）
- A BLAST analysis was used to suggest cross-reactivity with Anti-Bif-1 from Human based on 100 % homology with the immunizing sequence.
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纯化方法
- Anti-Bif-1 Antibody was purified by Protein G chromatography.
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免疫原
- Bif-1 Antibody was produced in mice and was prepared by repeated immunizations at the c-terminus of the human recombinant protein Bif-1.
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亚型
- IgG1 kappa
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anti-SH3-Domain GRB2-Like Endophilin B1 (SH3GLB1) (C-Term) antibody
Verified SH3GLB1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, FACS 宿主: 山羊 Polyclonal unconjugated
anti-SH3-Domain GRB2-Like Endophilin B1 (SH3GLB1) (AA 1-365) antibodySH3GLB1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1B3-A5 unconjugated
anti-SH3-Domain GRB2-Like Endophilin B1 (SH3GLB1) (AA 1-365) antibodySH3GLB1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SH3-Domain GRB2-Like Endophilin B1 (SH3GLB1) (C-Term) antibodySH3GLB1 适用: 人, 小鼠 WB, IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-SH3-Domain GRB2-Like Endophilin B1 (SH3GLB1) (AA 1-366) antibodySH3GLB1 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 1B3-A5 unconjugated
anti-SH3-Domain GRB2-Like Endophilin B1 (SH3GLB1) (AA 120-365) antibodySH3GLB1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-SH3-Domain GRB2-Like Endophilin B1 (SH3GLB1) (AA 59-86) antibodySH3GLB1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB15350 unconjugated
anti-SH3-Domain GRB2-Like Endophilin B1 (SH3GLB1) (AA 1-365) antibodySH3GLB1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-SH3-Domain GRB2-Like Endophilin B1 (SH3GLB1) (AA 58-107) antibodySH3GLB1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 兔, 马, 猴, 非洲爪蟾, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-SH3-Domain GRB2-Like Endophilin B1 (SH3GLB1) (N-Term) antibodySH3GLB1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optional[Neutralization_Dilution]: 1-2- μg/mL
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说明
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Anti-Bif-1 Antibody is tested for use in WB, ICC/IF, IHC, IHC-P, and IP. Expect a band approximately 23kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: 0.05 % BSA
Preservative: 0.05 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 6 months
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- SH3GLB1 (SH3-Domain GRB2-Like Endophilin B1 (SH3GLB1))
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别名
- SH3GLB1
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背景
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Synonyms: KIAA0491, Endophilin-B1, Bax-interacting factor 1, Bif-1, SH3 domain-containing GRB2-like protein B1
Background: Anti-Bif-1 Antibody detects human BIF. The Bcl-2 family consists of anti-apoptotic (or cell survival) genes, such as Bcl-2, Bcl-XL and pro-apoptotic (or cell death) genes including Bax and BAD. In addition to its anti-apoptotic effect, Bcl-2 also inhibits progression through the cell cycle. Functional interactions between family members as well as binding to other cellular proteins modulate their activities. Bcl-2 family members are important in normal tissue development, homeostasis, and disease states. Bcl-2 prevents cell death by forming heterodimers with Bax and Bad. Bax promotes cell death by forming homodimers, which can be blocked by forming heterodimers with Bcl-2 or BCL-XL. Recently, using yeast two-hybrid system Cuddeback have identified a cDNA encoding a 365 amino acid protein, which interacts physically with Bax protein and influences cell life and death. Bif-1 contains a Src homology 3 (SH3) domain in the C-terminus. It does not contain any of the conserved Bcl-2 homology (BH) domains of the Bcl-2 family proteins. Human Bif-1 protein shares 96 % and 42 % identity at the amino acids level with mouse and C. elegans, respectively. Overexpression of Bif-1 in transfected cell lines promotes Bax conformational change, caspase activation, and apoptotic cell death following growth factor withdrawal. Bif-1 RNA is abundantly expressed in heart, skeletal muscle, kidney, and placenta. Anti-BIF-1 antibody is ideal for investigators involved in cytokines and growth factor research and NFkappaB and signaling research.
Gene Name: SH3GLB1
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基因ID
- 51100
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NCBI登录号
- NP_001193580
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UniProt
- Q9Y371
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途径
- Autophagy
抗原
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