Bax Inhibitor 1 抗体
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北京 101111
Quick Overview for Bax Inhibitor 1 抗体 (ABIN6655585)
抗原
See all Bax Inhibitor 1 (TMBIM6) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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Supplier Product No.
- 200-301-h60
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Supplier
- Rockland
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原理
- BI1 Antibody
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交叉反应 （详细）
- A BLAST analysis was used to suggest cross-reactivity with Anti-Bi-1 from human, mouse and rat based on 100 % homology with the immunizing sequence.
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纯化方法
- Anti-Bi-1 Antibody was purified by Protein G chromatography.
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免疫原
- Bi-1 Antibody was produced in mice prepared by repeated immunizations of a mixture of three synthetic peptides corresponding to the N-terminus, internal and C-terminus of human Bi-1 protein.
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亚型
- IgG2b kappa
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anti-Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6) antibody
TMBIM6 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 20F565 unconjugated
anti-Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6) antibodyTMBIM6 适用: 人 WB 宿主: 小鼠 Monoclonal 20F248 unconjugated
anti-Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6) (AA 1-200) antibodyTMBIM6 适用: 人 WB 宿主: 小鼠 Monoclonal ABM20E4 unconjugated
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应用备注
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Immunohistochemistry_Dilution: 5-10 μg/mL
Western_Blot_Dilution: 1:500-1:1000
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说明
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Anti-Bi-1 antibody is tested for use in WB and IHC-P. Specific conditions for reactivity should be optimized by the end user.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: 0.2 % Gelatin
Preservative: 0.05 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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- Bax Inhibitor 1 (TMBIM6) (Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6))
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别名
- Bi-1
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背景
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Synonyms: BI1, TEGT, Bax inhibitor 1, BI-1, Testis-enhanced gene transcript protein,Transmembrane BAX inhibitor motif-containing protein 6
Background: Anti-Bi-1 antibody detects human Bi-1. BI-1 (Bax Inhibitor 1) is in anti-apoptotic protein that has been linked to protection from apoptosis induced endoplasmic reticulum (ER) stress (reviewed in Bailley-Maitre et al, 2007). BI-1 contains several transmembrane domains, localizes to ER membranes, and has cytoprotective functions that are conserved in both animals and plants. BI-1 suppresses apoptosis induced by ectopic expression of the proapoptotic protein Bax as well as other types of stimuli. Cells from BI-1 knockout (KO) mice are hypersensitivite to apoptosis induced by ER stress-causing chemical agents (thapsigargin, tunicamycin, and brefeldin A) or by ischemia-reperfusion (IR) injury. Conversely, overexpression of BI-1 protects against apoptosis induced by ER stress and IR. The mechanism by which BI-1 protects cells from ER-stress induced apoptosis remains to be fully elucidated, it is thought to involve regulation of Ca2+ handling by the ER. Anti-Bi-1 antibody is ideal for investigators involved in apoptosis research.
Gene Name: TMBIM6
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基因ID
- 7009
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NCBI登录号
- NP_001092046
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UniProt
- P55061
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途径
- Response to Water Deprivation, ER-Nucleus Signaling
抗原
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