Bax Inhibitor 1 抗体 (AA 1-200)
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- 抗原 See all Bax Inhibitor 1 (TMBIM6) 抗体
- Bax Inhibitor 1 (TMBIM6) (Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6))
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抗原表位
- AA 1-200
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Bax Inhibitor 1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- Protein G Chromatography
- 免疫原
- A partial length recombinant protein of human Bi-1 (amino acids 1-200) was used as an immunogen for this antibody.
- 克隆位点
- ABM20E4
- 亚型
- IgG2b kappa
- Top Product
- Discover our top product TMBIM6 Primary Antibody
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anti-Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6) (C-Term), (N-Term) antibody
TMBIM6 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal 20F430 unconjugated
anti-Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6) antibodyTMBIM6 适用: 人 WB 宿主: 小鼠 Monoclonal 20F248 unconjugated
anti-Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6) antibodyTMBIM6 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 20F565 unconjugated
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- 应用备注
- WB: 4-6 μg/mL
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- PBS containing 0.05 % BSA, PH 7.4
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- 抗原
- Bax Inhibitor 1 (TMBIM6) (Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6))
- 别名
- Bi-1 (TMBIM6 产品)
- 别名
- ARABIDOPSIS BAX INHIBITOR 1 antibody, ATBI-1 antibody, ATBI1 antibody, BAX INHIBITOR 1 antibody, BAX inhibitor 1 antibody, BI-1 antibody, K14A3.7 antibody, K14A3_7 antibody, BAXI1 antibody, TEGT antibody, 5031406P05Rik antibody, Bi1 antibody, Tegt antibody, Ab1-011 antibody, Ac1-149 antibody, Cc1-27 antibody, BAX inhibitor 1 antibody, transmembrane BAX inhibitor motif containing 6 antibody, BI1 antibody, TMBIM6 antibody, Tmbim6 antibody
- 背景
- Bi-1 is an anti-apoptotic protein that inhibits Bax activation and its translocation to the mitochondria. Functionally, BI-1 affects the leakage of Ca2+ ions from the ER. In addition to its anti-apoptotic role, BI-1 also enhances cancer/tumor progression. It belongs to the Bcl-2 family, plays an important role in the mitochondrial apoptosis pathway. Bi-1 over-expression suppresses apoptosis induced by Bax, staurosporine and growth factor deprivation. BI-1 is presumably not needed for the physiological regulation of developmental programmed cell death. The anti-apoptotic mechanism of BI-1 involves the suppression of Bax activation and translocation to mitochondria, preserving the mitochondria membrane potential and mitochondrial morphology, and preventing the activation of post-mitochondrial caspases. BI-1 function is also associated with the regulation of intracellular Ca2+ omeostasis. In several human cancers, including nasopharyngeal carcinoma, its expression was found to be increased, however, up-regulated expression of this protein has been linked to increased cell proliferations.
- 分子量
- 30 kDa
- 基因ID
- 7009
- UniProt
- P55061
- 途径
- Response to Water Deprivation, ER-Nucleus Signaling
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