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CD28 抗体 (PE)

CD28 适用: 人 FACS, IP, IHC 宿主: 小鼠 Monoclonal CD28-2 PE
Rockland
产品编号 ABIN6655121
Supplier Product No.: 200-308-n66
发货至: 中国
  • 抗原 See all CD28 抗体
    CD28
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    小鼠
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    标记
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    This CD28 antibody is conjugated to PE
    应用范围
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    Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (IHC)
    Supplier Product No.
    200-308-n66
    Supplier
    Rockland
    原理
    CD28 Phycoerythrin Antibody
    交叉反应 (详细)
    Reactivity is observed against human CD28, Baboon, Chimpanzee, Cynomolgus, and Rhesus.
    纯化方法
    Phycoerythrin conjugated CD28 Monoclonal Antibody was purified from tissue culture supernatant via affinity chromatography and is directed against human CD28.
    过滤
    Sterile filtered
    免疫原
    Anti-CD28 Antibody (Monoclonal) was produced by repeated immunizations with CD28 antigen.
    克隆位点
    CD28-2
    亚型
    IgG1 kappa
    Labeling Ratio
    1-2
    Top Product
    Discover our top product CD28 Primary Antibody
  • 应用备注

    Immunoprecipitation_Dilution: User Optimized

    Immunohistochemistry_Dilution: User Optimized

    Flow_Cytometry_Dilution: 5μL/test/1x10e5 to 1x10e8 cells

    说明

    Anti-CD28 is tested for Flow Cytometry and is useful in Immunoprecipitation and Immunohistochemistry. Researchers should determine optimal titers for applications that are not stated.

    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液

    Buffer: 0.01 M Sodium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: 0.1 % Gelatin

    Preservative: 0.09 % (w/v) Sodium Azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store vial at 4° C prior to opening. Dilute only prior to immediate use. This product is stable at 4° C as an undiluted liquid. Use subdued lighting during handling and incubation of cells prior to analysis. Store reagent in the dark. DO NOT FREEZE.
    有效期
    6 months
  • 抗原
    CD28
    别名
    CD28 (CD28 产品)
    背景

    Synonyms: T-cell-specific surface glycoprotein CD28, TP44, CD28

    Background: The CD28 antibody reacts with human CD28, a 44 kDa type I surface glycoprotein which acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, known as B7-1 (CD80) and B7-2 (CD86), which are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. Other members of the CD28 family of receptors include CTLA-4 (CD152), PD-1 (CD279), ICOS and BTLA. The CD28.2 antibody may be used as a phenotypic marker for human CD28, expressed on all CD4+ T cells and CD8+ T cells, and is widely used as a reagent for activation of the CD28 receptor in vitro and in vivo.

    Gene Name: CD28

    基因ID
    940
    NCBI登录号
    NP_001230006
    UniProt
    P10747
    途径
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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