ATF6 抗体 (N-Term)
Quick Overview for ATF6 抗体 (N-Term) (ABIN6655070)
抗原
See all ATF6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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Supplier Product No.
- 600-401-gu9
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Supplier
- Rockland
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原理
- ATF6 Antibody
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交叉反应 （详细）
- This affinity purified antibody is directed against human ATF6.
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纯化方法
- This product was affinity purified from monospecific antiserum by immunoaffinity purification.
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过滤
- Sterile filtered
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免疫原
- Anti-ATF6 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a N-Term portion of human ATF6 conjugated to Keyhole Limpet Hemocyanin (KLH).
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亚型
- IgG
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anti-Activating Transcription Factor 6 (ATF6) (AA 1-190) antibody
ATF6 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 6 (ATF6) (AA 1-377) antibodyATF6 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 6 (ATF6) (AA 437-449) antibodyVerified ATF6 适用: 人 WB, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Activating Transcription Factor 6 (ATF6) (AA 301-400) antibodyATF6 适用: 人 WB, ELISA, IF (p), IF (cc), IHC (p), FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 6 (ATF6) (AA 350-377) antibodyATF6 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB22035 unconjugated
anti-Activating Transcription Factor 6 (ATF6) (AA 350-377) antibodyATF6 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 6 (ATF6) (AA 423-646) antibodyATF6 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 6 (ATF6) (AA 91-193) antibodyATF6 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3D5 unconjugated
anti-Activating Transcription Factor 6 (ATF6) (N-Term) antibodyATF6 适用: 人 WB, IP 宿主: 小鼠 Monoclonal 1-7 unconjugated
anti-Activating Transcription Factor 6 (ATF6) (N-Term) antibodyATF6 适用: 人, 小鼠 WB, IP 宿主: 小鼠 Monoclonal 37-1 unconjugated
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应用备注
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Immunoprecipitation_Dilution: User Optimized
ELISA_Dilution: 5.0 μg/mL
Immunohistochemistry_Dilution: 1:200
Flow_Cytometry_Dilution: User Optimized
IF_Microscopy_Dilution: 10 μg/mL
Western_Blot_Dilution: 0.5 μg/mL
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说明
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Anti-ATF6 Antibody has been tested in Western Blot, IF and ELISA. Recombinant ATF6 protein positive control was used for western blotting. Expect a band at 74.5kDa in western blot using appropriate lysates or recombinant protein. Antibody tested positive in U251 cells (W09-001-GY4) in Immunofluorescence. Although not tested, this antibody is likely functional in immunohistochemistry, flow cytometry, and immunoprecipitation.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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- ATF6 (Activating Transcription Factor 6 (ATF6))
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别名
- ATF6
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背景
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Synonyms: rabbit anti-ATF6 Antibody, Activating Transcription Factor 6, rabbit anti-ATF-6 Antibody, Cyclic AMP-dependent transcription factor ATF-6 alpha, Activating transcription factor 6 alpha, ATF6 alpha
Background: ATF6 belongs to the bZIP (basic-leucine zipper domain transcription factor) family. Activating target genes for the unfolded protein response during endoplasmic reticulum stress. Embeded in the endoplasmic reticulum, it functions as an ER stress sensor/stress transducer. Following stress-induced proteolysis it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. ATF6 could also be involved in the activation of transcription by the serum response factor. This protein may play a role in the development of the foveal and cone function in the retina. Therefore, attributing to disorders such as achromatopsia, blindness, nystagmus, myopia, cataracts and more. Anti-ATF6 Antibody is useful for researchers studying eye development, protein folding and processing, Endoplasmic Reticulum Stress Pathways, Glucose and Energy Metabolism Research.
Gene Name: ATF6
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基因ID
- 22926
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NCBI登录号
- NP_031374
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UniProt
- P18850
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途径
- ER-Nucleus Signaling, Unfolded Protein Response
抗原
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