ABCA4 抗体
(1 reference)
Quick Overview for ABCA4 抗体 (ABIN6655047)
抗原
See all ABCA4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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Supplier Product No.
- 200-301-d05
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Supplier
- Rockland
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原理
- ABCA4 Rim Protein Antibody
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交叉反应 （详细）
- Anti-ABCA4 antibody is directed against bovine ABCA4 Rim Protein.
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纯化方法
- The antibody was Protein G purified from culture supernatant.
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免疫原
- Anti-ABCA4 antibody was produced by repeated immunizations with 220-kDa (full length) partially purified native bovine disc rim protein.
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亚型
- IgG
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anti-ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) (AA 2250-2263) antibody
Verified ABCA4 适用: 人, 小鼠 ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) (AA 1398-1727) antibodyABCA4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) antibodyABCA4 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) (AA 2174-2273) antibodyABCA4 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) (C-Term) antibodyABCA4 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) antibodyABCA4 适用: Cow WB, IHC 宿主: 小鼠 Monoclonal 3F4 unconjugated
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应用备注
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ELISA_Dilution: 1:10,000
Immunohistochemistry_Dilution: 1:100
Western_Blot_Dilution: 1:1000
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说明
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Suggested Applications: IF
Anti-ABCA4 antibody has been tested by western blot and IHC and is suitable for use in ELISA. Specific conditions should be optimized by the end user. Expect a band of ~220kDa in size corresponding to ABCA4 proteins in the appropriate cell lysate or extract. -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
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有效期
- 12 months
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: "Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution." in: Cell, Vol. 182, Issue 6, pp. 1623-1640.e34, (2021) (PubMed).
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: "Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution." in: Cell, Vol. 182, Issue 6, pp. 1623-1640.e34, (2021) (PubMed).
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- ABCA4 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4))
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别名
- ABCA4 Rim Protein
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背景
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Synonyms: Retinal-specific ATP-binding cassette transporter, ATP-binding cassette sub-family A member 4, RIM ABC transporter
Background: ABCA4 antibody detects ABCA4 (ATP-binding cassette, sub-family A (ABC1), member 4, Rim Protein) a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABCA4 is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essential molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease and are associated with retinitis pigmentosa-19 and age-related macular degeneration. Defects in ABCA4 are the cause of Stargardt disease type 1 (STGD1). STGD is one of the most frequent causes of macular degeneration in childhood. Defects in ABCA4 are also known to cause fundus flavimaculatus (FFM), age-related macular degeneration type 2 (ARMD2) and cone-rod dystrophy type 3 (CORD3). Anti-ABCA4 antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.
Gene Name: ABCA4
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基因ID
- 11304
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NCBI登录号
- NP_776646
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UniProt
- O35600
抗原
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