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MUC3A 抗体

This 兔 单克隆 antibody specifically detects MUC3A in IHC (p). It exhibits reactivity toward 人.
产品编号 ABIN6654972
发货至: 中国
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Quick Overview for MUC3A 抗体 (ABIN6654972)

抗原

MUC3A (Mucin 3A, Cell Surface Associated (MUC3A))

适用

  • 50
  • 2
  • 2

宿主

  • 42
  • 12

克隆类型

  • 31
  • 23
单克隆

标记

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  • 1
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This MUC3A antibody is un-conjugated

应用范围

  • 21
  • 13
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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

MUC3-2992R
  • 纯化方法

    Purified

    纯度

    Protein A affinity chromatography

    免疫原

    Amino acids (C-HSTPSFTSSITTTETTSHSTPSFTSSITTTETTS) which contains two of the MUC3 tandem repeats was used as the immunogen for the MUC3 antibody.

    亚型

    IgG kappa
  • 应用备注

    Optimal dilution of the recombinant MUC3 antibody should be determined by the researcher.

    1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 1-2 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)

    限制

    仅限研究用
  • 缓冲液

    1 mg/mL in 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    4 °C,-20 °C

    储存方法

    Store the recombinant MUC3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
  • 抗原

    MUC3A (Mucin 3A, Cell Surface Associated (MUC3A))

    别名

    MUC3

    背景

    It recognizes a protein of HMW, identified as mucin 3 glycoprotein (MUC3). Its epitope localizes between aa SITTTE. This MAb shows no cross-reaction with human milk fat globule membranes, MUC1, or MUC2. MUC3 is distributed in colon and rectum, and is also present to a lesser extent in breast, lung and salivary gland tissues. The Mucins are a family of highly glycosylated, secreted proteins with a basic structure consisting of a variable number of tandem repeats (VNTRs) encoded by 60 base pairs (Mucin 1), 69 base pairs (Mucin 2) and 51 base pairs (Mucin 3). The number of repeats is highly polymorphic and varies among different alleles. Mucin 1 proteins are expressed as type I membrane proteins in addition to secreted forms. Mucin 1 is aberrantly expressed in epithelial tumors including breast carcinomas. Mucin 2 coats the epithelia of the intestines and airways and is associated with colonic tumors. Mucin 3 is a major component of various mucus gels and is broadly expressed in normal and tumor cells.
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