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Aurora Kinase B 抗体 (AA 89-251)

This anti-Aurora Kinase B antibody is a 兔 单克隆 antibody detecting Aurora Kinase B in IHC (p). Suitable for 人.
产品编号 ABIN6654233
发货至: 中国

Quick Overview for Aurora Kinase B 抗体 (AA 89-251) (ABIN6654233)

抗原

See all Aurora Kinase B (AURKB) 抗体
Aurora Kinase B (AURKB)

适用

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宿主

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克隆类型

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单克隆

标记

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This Aurora Kinase B antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

ARRK2-2R
  • 抗原表位

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    AA 89-251

    纯化方法

    Purified

    纯度

    Protein A affinity

    免疫原

    A portion of amino acids 89-251 was used as the immunogen for this recombinant AURKB antibody.

    亚型

    IgG kappa
  • 应用备注

    Optimal dilution of the recombinant AURKB antibody should be determined by the researcher.\. IHC (FFPE): 1-2 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)

    限制

    仅限研究用
  • 缓冲液

    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store the recombinant AURKB antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
  • 抗原

    Aurora Kinase B (AURKB)

    别名

    Aurora B / AURKB

    背景

    Recognizes a protein of 39 kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.

    途径

    TCR Signaling, Cell Division Cycle, Maintenance of Protein Location, Hepatitis C, Toll-Like Receptors Cascades
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