Hsc70 抗体
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北京 101111
Quick Overview for Hsc70 抗体 (ABIN6653942)
抗原
See all Hsc70 (HSPA8) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Reacts with human Hsc70 (Hsp73). Cross-reacts with mouse, rat, rabbit, guinea pig, hamster, monkey, sheep, chicken, bovine, canine and porcine protein.
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纯化方法
- Purified (protein G)
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免疫原
- Hsc70 purified from sodium arsenite treated heat-resistant variants of Chinese hamster cells.
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亚型
- IgG2a
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应用备注
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Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
WB0.1 μg/mL IP5 μg/mL IHC5 μg/mL ICC5 μg/mL
Positive control: HeLa Heat Shocked Cell Lysate -
限制
- 仅限研究用
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缓冲液
- PBS pH 7.2, 0.1 mM PMSF in 50 % glycerol.
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储存液
- PMSF
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储存条件
- 4 °C/-20 °C
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储存方法
- Store frozen product at or below -20°C. Thawed product may be stored for 2-4 weeks at 4°C. For optimal storage, aliquot and store at -20°C.
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- Hsc70 (HSPA8) (Heat Shock 70kDa Protein 8 (HSPA8))
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别名
- Hsc70 (Hsp73)
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背景
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Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes
Heat shock cognate 71 kDa protein Heat shock 70 kDa protein 8 Lipopolysaccharide-associated protein 1, LAP-1, LPS-associated protein 1 Gene name: HSPA8, HSC70, HSP73, HSPA10 -
基因ID
- 3312
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UniProt
- P11142
抗原
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