GSTA1 抗体
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北京 101111
Quick Overview for GSTA1 抗体 (ABIN659176)
抗原
See all GSTA1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
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免疫原
- This GSTA1 monoclonal antibody is generated from mouse immunized with GSTA1 recombinant protein.
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亚型
- IgM kappa
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应用备注
- WB: 1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- GSTA1 Antibody can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
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有效期
- 6 months
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- GSTA1 (Glutathione S-Transferase alpha 1 (GSTA1))
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别名
- GSTA1
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背景
- Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.
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分子量
- 25631
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基因ID
- 2938
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NCBI登录号
- NP_665683
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UniProt
- P08263
抗原
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