NUMBL 抗体 (C-Term)
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Quick Overview for NUMBL 抗体 (C-Term) (ABIN658002)
抗原
See all NUMBL 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 572-600, C-Term
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This NUMBL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 572-600 amino acids from the C-terminal region of human NUMBL.
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亚型
- Ig Fraction
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anti-Numb Homolog (Drosophila)-Like (NUMBL) (AA 447-576) antibody
NUMBL 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Numb Homolog (Drosophila)-Like (NUMBL) (C-Term) antibodyNUMBL 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Numb Homolog (Drosophila)-Like (NUMBL) (N-Term) antibodyVerified NUMBL 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
- WB: 1:1000. IHC-P: 1:10~50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- NUMBL Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
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有效期
- 6 months
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- NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))
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别名
- NUMBL
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背景
- NUMBL plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
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分子量
- 64891
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基因ID
- 9253
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NCBI登录号
- NP_004747
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UniProt
- Q9Y6R0
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途径
- Cell-Cell Junction Organization
抗原
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