DYRK2 抗体 (C-Term)
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Quick Overview for DYRK2 抗体 (C-Term) (ABIN657991)
抗原
See all DYRK2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 521-549, C-Term
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This Mouse Dyrk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-549 amino acids from the C-terminal region of mouse Dyrk2.
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亚型
- Ig Fraction
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应用备注
- WB: 1:2000. WB: 1:1000. WB: 1:8000. IHC-P: 1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Mouse Dyrk2 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
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有效期
- 6 months
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- DYRK2 (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 2 (DYRK2))
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别名
- Dyrk2
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背景
- Role in the regulation of cellular growth and/or development. Regulates TP53 by phosphorylation on Ser-46 to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates (By similarity).
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分子量
- 66556
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基因ID
- 69181
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NCBI登录号
- NP_001014412
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UniProt
- Q5U4C9
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途径
- Regulation of Carbohydrate Metabolic Process
抗原
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