Complement C4A/C4B (AA 721-770) 抗体
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Quick Overview for Complement C4A/C4B (AA 721-770) 抗体 (ABIN6579207)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 721-770
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原理
- C4a/b Antibody
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特异性
- C4a/b Polyclonal Antibody detects endogenous levels of C4a/b protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- The antiserum was produced against synthesized peptide derived from the Internal region of human C4A/C4B. AA range:721-770
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亚型
- IgG
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anti-Complement C4A/C4B (Internal Region) antibody
适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Complement C4A/C4B (Center) antibody适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- Complement C4A/C4B
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别名
- C4A/B
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背景
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Synonyms: C4A, CO4, CPAMD2, Complement C4-A, Acidic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2, C4B, CO4, CPAMD3, Complement C4-B, Basic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3
Background: This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided
Gene Name: C4A/C4B
Protein Name: Complement C4-A/Complement C4-B
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分子量
- '192 kDa
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基因ID
- 720, 721
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OMIM
- 120810
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UniProt
- P0C0L4
抗原
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