LAMC2 抗体 (AA 941-970)
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Quick Overview for LAMC2 抗体 (AA 941-970) (ABIN657905)
抗原
See all LAMC2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 941-970
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This LAMC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 941-970 amino acids from the Central region of human LAMC2.
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亚型
- Ig Fraction
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anti-Laminin, gamma 2 (LAMC2) (AA 28-196) antibody
LAMC2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Laminin, gamma 2 (LAMC2) (AA 416-602) antibodyLAMC2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Laminin, gamma 2 (LAMC2) (AA 862-1111) antibodyLAMC2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Laminin, gamma 2 (LAMC2) (C-Term) antibodyLAMC2 适用: 人, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Laminin, gamma 2 (LAMC2) (AA 417-588) antibodyLAMC2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Laminin, gamma 2 (LAMC2) (AA 1084-1193) antibodyLAMC2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Laminin, gamma 2 (LAMC2) antibodyLAMC2 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Laminin, gamma 2 (LAMC2) (AA 28-196) antibodyLAMC2 适用: 人 WB 宿主: 小鼠 Monoclonal D7 unconjugated
anti-Laminin, gamma 2 (LAMC2) antibodyLAMC2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Laminin, gamma 2 (LAMC2) (AA 1160-1180), (C-Term) antibodyLAMC2 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- LAMC2 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
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有效期
- 6 months
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- LAMC2 (Laminin, gamma 2 (LAMC2))
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别名
- LAMC2
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背景
- Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain, however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature.
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分子量
- 130976
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基因ID
- 3918
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NCBI登录号
- NP_005553, NP_061486
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UniProt
- Q13753
抗原
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